Changes of the 78 kDa glucose-regulated protein (grp78) in livers of diabetic rats
Szántó, I.; Gergely, P.; Marcsek, Z.; Bányász, T.; Somogyi, J.; Csermely, P.
Acta Physiologica Hungarica 83(4): 333-342
The 78 kDa glucose-regulated protein (grp78) is an abundant member of the 70 kDa molecular chaperone family in the lumen of the endoplasmic reticulum participating in the quality control of secretory proteins. In the present paper we have analysed the synthesis and level of grp78 in livers of control, streptozotocin-diabetic, and the spontaneously diabetic Zucker rats. The level of grp78 mRNA significantly decreased in streptozotocin-diabetic rats. The effect was reversed by insulin treatment.