Characterization of the mouse gene encoding phospholipid transfer protein

Tu, A.Y.; Chen, H.; Johnson, K.A.; Paigen, B.; Albers, J.J.

Gene 188(1): 115-118


ISSN/ISBN: 0378-1119
PMID: 9099868
DOI: 10.1016/s0378-1119(96)00793-7
Accession: 008302382

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The mouse gene encoding phospholipid transfer protein (PLTP) was cloned from 129/SvJ lambda-FIX-R II library and characterized for the first time. It is comprised of 16 exons separated by 15 introns. Its gene organization strikingly resembles that encoding the human PLTP; the exon-intron junctions in these two genes are completely conserved. Sequencing analysis reveals that the putative promoter of mouse PLTP gene consists of a TATA-box, a high GC region, and several consensus sequences for the binding of transcription factors. Within the first 200 bp of the 5'-flanking region, the mouse and human PLTP genes share 8 1.1% identity of nt sequences and contain the consensus sequences for the transcription factors AP-2 and Sp1 at the same locations.