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Charcoal hemoperfusion as treatment for Carbamazepine acute intoxication



Charcoal hemoperfusion as treatment for Carbamazepine acute intoxication



Acta Anaesthesiologica Italica 46(2-3): 191-194



The authors describe a deep coma following a suicide with 8 gr of Carbamazepine (CBZ) in 45 year old patient taking this drug for epilepsy. The authors performed two session three hours long every 12 hours of hemoperfusion (HP) to increase the excretion of this drug. At the beginning CBZ plasmatic concentration was 48.9 mu-gr/ml (therapeutic range 4-12 mu-gr/ml). After the first session, the plasmatic concentration of CBZ was 30.6 mu-gr/ml, after the second session was 5.2 mu-gr/ml. The coma improved after the first session of EP with a partial breathing recovery. The patient recovered completely the breathing and his consciousness status after 24 hours. Although in this case report, a deep coma due to intoxication with CBZ, has been resolved with HP, further studies are necessary to confirm the efficacy of CBZ.

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Accession: 008304065

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