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Chiral separation of monoterpenes using mixtures of sulfated beta-cyclodextrins and alpha-cyclodextrin as chiral additives in the reversed-polarity capillary electrophoresis mode



Chiral separation of monoterpenes using mixtures of sulfated beta-cyclodextrins and alpha-cyclodextrin as chiral additives in the reversed-polarity capillary electrophoresis mode



Journal of Chromatography A 759(1-2): 149-155



The use of mixtures of sulfated beta-cyclodextrins and native alpha-cyclodextrin as chiral additives in capillary electrophoresis was evaluated for the chiral resolution of neutral, cyclic and bicyclic monoterpenes, including alpha-pinene, beta-pinene, camphene and limonene. Binding properties of sulfated beta-cyclodextrins towards these monoterpenes were studied. It was found that there was no enantioresolution of these terpenoids over the concentration range studied. However, the addition of alpha-cyclodextrin to the running electrolyte in addition to 6.5 mM sulfated beta-cyclodextrins, imparted differences in the mobilities of the terpenoid enantiomers and resulted in remarkable enantiomeric separations of alpha-pinene (R-s=25), beta-pinene (R-s = 12), camphene (R-s = 12) and limonene (R-s =4). The role of both alpha-cyclodextrin and sulfated beta-cyclodextrins in these separations is discussed.

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Accession: 008309564

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