+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Cholecystokinin and neuropeptide Y receptors on single rabbit vagal afferent ganglion neurons: Site of prejunctional modulation of visceral sensory neurons

Cholecystokinin and neuropeptide Y receptors on single rabbit vagal afferent ganglion neurons: Site of prejunctional modulation of visceral sensory neurons

Brain Research 633(1-2): 33-40

A [125I]cholecystokinin (CCK) analog and [125I]peptide YY (PYY) were used to localize and characterize CCK and neuropeptide Y (NPY) receptor binding sites in the rabbit vagal afferent (nodose) ganglion. High concentrations of CCK and NPY binding sites were observed in 10.6% and 9.2% of the nodose ganglion neurons, respectively. Pharmacological experiments using CCK or NPY analogs suggest that both subtypes of CCK (CCK-A and CCK-B) and NPY (Y1 and Y2) receptor binding sites are expressed by discrete populations of neurons in the nodose ganglion. These results suggest sites at which CCK or NPY, released in either the nucleus of the solitary tract or a peripheral tissue, may modulate the release of neurotransmitters from a select population of visceral primary afferent neurons. Possible functions mediated by these receptors include modulation of satiety, opiate analgesia, and the development of morphine tolerance.

(PDF emailed within 0-6 h: $19.90)

Accession: 008311255

Download citation: RISBibTeXText

PMID: 8137166

DOI: 10.1016/0006-8993(94)91519-9

Related references

Characterization of cholecystokinin-A and cholecystokinin-B receptors expressed by vagal afferent neurons. Neuroscience. 79(3): 905-913, 1997

Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin. Journal of Neuroscience 24(11): 2708-2715, 2004

Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach. Journal of Neuroscience 28(45): 11583-11592, 2008

Vagal afferent-dependent cholecystokinin modulation of visceral pain requires central amygdala NMDA-NR2B receptors in rats. Neurogastroenterology and Motility 27(9): 1333-1343, 2016

Tyrosine-hydroxylase-containing vagal afferent neurons in the rat nodose ganglion are independent from neuropeptide-Y-containing populations and project to esophagus and stomach. Cell and Tissue Research 271(1): 135-144, 1993

Discrete localization within the rat nodose ganglion of vagal afferent sensory neurons innervating the gastrointestinal tract. Gastroenterology 118(4 Suppl 2 Part 1): A80, 2000

Properties of visceral primary afferent neurons in the nodose ganglion of the rabbit. Journal of Neurophysiology 54(2): 245-260, 1985

Increase in neuroexcitability of unmyelinated C-type vagal ganglion neurons during initial postnatal development of visceral afferent reflex functions. Cns Neuroscience and Therapeutics 19(12): 954-962, 2014

Visceral pain modulation in female primary afferent sensory neurons. Current Trends in Neurology 9: 111-114, 2015

Modulation of norepinephrine release from sympathetic neurons of the rabbit aorta by prejunctional prostanoid receptors. Journal of Pharmacology and Experimental Therapeutics 291(1): 7-11, 1999

A possible modulation of sensory transmission by opioid peptides at primary afferent neurons in trigeminal ganglion. Cros, J , J -C Meunier And M Hamon (Ed ) Advances in The Biosciences, Vol 75 Progress in Opioid Research; 19th International Narcotics Research Conference, Albi, France, July 3-8, 1988 Xix+782p Pergamon Press: Oxford, England, Uk; New York, New York, Usa Illus 427-430, 1989

Inhibition of axoplasmic transport in the rat vagus nerve alters the numbers of neuropeptide and tyrosine hydroxylase messenger RNA-containing and immunoreactive visceral afferent neurons of the nodose ganglion. Neuroscience. 66(1): 175-187, 1995

Somatostatin and neuropeptide y inhibit an inward calcium current in vagal sensory neurons modulation via the inhibitory guanine nucleotide regulatory complex. Gastroenterology 94(5 PART 2): A497, 1988

Recording of the activity of several neurons of the plexiform ganglion using a single microelectrode. Application to the study of the conduction speed of afferent vagal fibers. Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales 160(5): 1024-1029, 1966

5 hydroxy tryptamine receptors of visceral primary afferent neurons on rabbit nodose ganglia. Journal of Physiology (Cambridge) 323: 543-568, 1982