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Cholera toxin B subunit (CTB) entrapped in microparticles shows comparable immunogenicity to CTB mixed with whole cholera toxin following oral immunization



Cholera toxin B subunit (CTB) entrapped in microparticles shows comparable immunogenicity to CTB mixed with whole cholera toxin following oral immunization



International Journal of Pharmaceutics (Amsterdam) 119(2): 251-255



Cholera toxin B subunit (CTB) was entrapped in poly(lactide-co-glycolide) microparticles and the responses induced by microencapsulated CTB were comparable to those induced by oral immunization with CTB mixed with whole cholera toxin. In addition, the CTB was released from microparticles intact following in vitro incubation, as determined by the ability of the CTB to bind to its cellular receptor, GM1. Moreover, microencapsulated CTB induced serum antibodies against intact CTB and not against monomeric fragments.

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Accession: 008311497

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DOI: 10.1016/0378-5173(95)00046-l


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