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Circadian rhythms in plasma cortisone and cortisol and the cortisone/cortisol ratio



Circadian rhythms in plasma cortisone and cortisol and the cortisone/cortisol ratio



Clinica Chimica Acta 266(2): 83-91,. 31



We evaluated the circadian rhythms in the plasma concentrations of cortisol, cortisone and their free forms, and in the cortisone/cortisol ratios by means of reversed-phase high performance liquid chromatography in normal adult subjects. Plasma concentrations of cortisone, as well as cortisol, exhibited a circadian rhythm. The ratios of cortisone/cortisol remained almost constant during the waking hours of normal subjects. Changes in the cortisone/cortisol ratios previously reported in patients with various diseases exceeded the diurnal changes detected in the present study. Thus, the determination of the cortisone/cortisol ratio provides information that is useful in assessing the adrenal function of patients with various diseases.

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Accession: 008319073

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DOI: 10.1016/s0009-8981(97)00142-3


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