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Clinical characteristics of ventricular arrhythmia in NIDDM: Evaluation of arrhythmia using Holter ECG monitoring

Clinical characteristics of ventricular arrhythmia in NIDDM: Evaluation of arrhythmia using Holter ECG monitoring

Journal of the Japan Diabetes Society 37(5): 349-355

We have reported that the prevalence of sudden death in diabetic subjects is higher than that in the general population, but the precise mechanism of sudden death in diabetics is still unclear. Malignant arrhythmia might be one of the possible causes of sudden death. Herein, we have investigated the frequency and clinical characteristics of ventricular premature contraction (VPC) using 24 hr-Holter ECG monitoring in 444 NIDM (group D), and in 80 age and sex matched non-diabetic controls (group C) without organic heart disease. 1) In group D, Multifocal VPC, ventricular tachycardia and/or R-on-T phenomenon were more frequently observed as compared with controls. 2) Malignant arrhythmia in group D was associated with aging, ischemic heart disease, nephropathy, and autonomic neuropathy. These results indicate that further cardiac examination using Holter ECG should be recommended for diabetics with cardiac complications nephropathy, and/or autonomic neuropathy in order to prevent sudden unexpected death.

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