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Clinical significance of serum c-erbB-2 protein in patients with primary breast cancer



Clinical significance of serum c-erbB-2 protein in patients with primary breast cancer



Oncology Reports 4(2): 349-352



We measured serum c-erbB-2 protein concentration in 167 patients with primary breast cancer. The rate of positive results was 6%. The positivity rate of serum c-erbB-2 protein did not differ among stages I, II, IIIa and IIIb. However the positivity rate on stage IV was 50% (3/6) and significantly higher than the other stages (p=0.0006). The rate of positive results correlated significantly with lymph node status (p=0.0037). We concluded that the level of serum c-erbB-2 protein reflected the malignant characteristics of primary breast cancer and its measurement may be useful for a preoperative evaluation of primary breast cancer.

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Accession: 008328288

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PMID: 21590057


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