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Coenzyme Q content in synaptic and non-synaptic mitochondria from different brain regions in the ageing rat

Coenzyme Q content in synaptic and non-synaptic mitochondria from different brain regions in the ageing rat

Mechanisms of Ageing and Development 78(3): 173-187

We investigated the Coenzyme Q (CoQ) content of different mitochondrial fractions (free mitochondria (FM), synaptic heavy (HM) and light mitochondria (LM)) from three brain areas (cortex, striatum, hippocampus) of rats at different ages. In rats from 2 to 26 months of age, we observed only small differences in total CoQ content (CoQ-9 + CoQ-10). In FM and LM fractions, values are very similar and appear to be much higher than in HM fractions. The CoQ-10/CoQ-9 ratios are much higher in brain mitochondria than in other organs, suggesting possible modifications of CoQ biosynthetic pathways in brain; nevertheless they appear to remain constant during ageing. CoQ-9 and CoQ-10 contents slowly decrease reaching their minimum in rats of 18 months of age, then increase in the older ages. Considering ageing as partially driven by a summation of free radical-mediated processes, we can hypothesize that damage occurring to biological structures in the first half of life might be followed by induction phenomena tending to re-establish the primitive levels of antioxidant molecules.

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Accession: 008339424

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PMID: 7596200

DOI: 10.1016/0047-6374(94)01535-t

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