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Comparative treatment planning between proton and X-ray therapy in locally advanced rectal cancer



Comparative treatment planning between proton and X-ray therapy in locally advanced rectal cancer



Radiotherapy & Oncology. 41(3): 263-272



Background and purpose: Conformal treatment planning with megavoltage X-rays and protons for medically inoperable patients with a large rectal cancer has been studied in an attempt to determine if there are advantages of using protons instead of X-rays. Material and methods: Three dose plans were made for each of the six patients: one proton plan, including three beams covering the primary turnout and adjacent lymph nodes and three boost beams covering the primary tumour; one X-ray plan, eight beams including a boost with four beams and one mixed plan with four X-ray beams and a boost with three proton beams. A three-dimensional treatment-planning system, TMS, was used. The evaluation of the different plans was made by applying the biological models TCP and NTCP on the dose distributions in terms of dose-volume histograms. Results: The comparison shows advantages of using protons instead of X-rays for all six patients, but in three of them, the advantage is only marginal. The dose-limiting organ at risk is the small bowel, but the proton plan and the mixed plan also spare the bladder and the femoral heads better. At 5% NTCP in any risk organ, the calculated mean TCP value for the six patients is increased by 14%-units with the proton plan and 8%-units with the mixed plan compared to X-rays only. Conclusions: Proton beam therapy has potential advantages when treating medically inoperable patients with a large rectal cancer over conventional X-ray therapy. Since the benefits are comparatively small, although clinically worthwhile, large randomized studies are needed.

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Accession: 008353366

Download citation: RISBibTeXText

PMID: 9027943

DOI: 10.1016/s0167-8140(96)01851-8


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