Comparison of effects of nicardipine and trichlormethiazide on insulin sensitivity in hypertensive patients
Kageyama, S.; Yamamoto, J.; Mimura, A.; Ishibashi, K.; Sakurai, T.; Yokota, K.; Isogai, Y.; Fujita, T.
American Journal of Hypertension 7(5): 474-477
ISSN/ISBN: 0895-7061 PMID: 8060584 Accession: 008357373
We performed a randomized, crossover study comparing the effects of nicardipine and trichlormethiazide on insulin sensitivity in 8 untreated essential hypertensive patients. They were treated either with nicardipine or trichlormethiazide for 12 weeks, after which they were treated with the alternative drug for a further 12 weeks. Insulin sensitivity was determined by the hyperinsulinemic euglycemic clamp technique. Nicardipine had no adverse effect on insulin sensitivity. Trichlormethiazide decreased insulin sensitivity index by 12%. As nicardipine does not have an adverse effect on insulin sensitivity, it should be preferred in patients who have a proven metabolic abnormality.