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Comparison of effects of uroguanylin, guanylin, and Escherichia coli heat-stable enterotoxin STa in mouse intestine and kidney: evidence that uroguanylin is an intestinal natriuretic hormone


, : Comparison of effects of uroguanylin, guanylin, and Escherichia coli heat-stable enterotoxin STa in mouse intestine and kidney: evidence that uroguanylin is an intestinal natriuretic hormone. Journal of Investigative Medicine 45(5): 276-282

Background: Uroguanylin and guanylin are intestinal peptides that activate a receptor-guanylate cyclase, which is also a receptor for Escherichia coli heat-stable enterotoxin (STa). These peptides may have a role in the body's regulation of fluid and electrolytes. Methods: STa, bioactive guanylin, and bioactive uroguanylin were evaluated for effects in: 1) the suckling mouse intestinal fluid secretion assay; 2) an in vitro suckling mouse intestinal loop assay; 3) an intestinal receptor autoradiography assay; 4) a control or agonist-stimulated assay for cGMP response in T84 cells; and 5) an in vivo renal function assay in mice. Results: In vivo, orally administered uroguanylin and STa but not guanylin, stimulated intestinal fluid secretion. All three peptides activated intestinal guanylate cyclase and had common intestinal receptors. In vitro, after pretreatment with chymotrypsin, only uroguanylin and STa retained agonist activity. Chymostatin preserved guanylin activity. STa and uroguanylin induced diuresis, natriuresis, and kaliuresis. Guanylin was less potent than uroguanylin and STa. Conclusions: The results suggest that the endogenous intestinal peptides, uroguanylin and guanylin, regulate water and electrolyte homeostasis both through local effects on intestinal epithelia and endocrine effects on the kidney.

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McNaughton, I. H., 1973: Synthesis and sterility of Raphanobrassica. The synthesis of Raphanobrassica (2n = 36, rrcc) from Raphanus sativus (2n = 18, cc) and Brassica oleracea (2n = 18, cc) is described. Both colchicine treatment of diploid hybrids and the crossing of autotetraploid forms of the parents were succes...

Freund, Hans Joachim, 1996: Pathophysiology of upper motoneurone disorders. Bostock, H [Editor], Kirkwood, P A [Editor], Pullen, A H [Editor] The neurobiology of disease: Contributions from neuroscience to clinical neurology 276-282

Chochillon, C.; Favennec, L.; Gobert, J. G.; Savel, J., 1990: Giardia intestinalis: studies of infection modality in suckling mice. The modalities of experimental G. intestinalis infection were studied in suckling NMRI mice. Cysts given by mouth did not produce infection in 5-day-old NMRI mice irrespective of strain (7 strains isolated from human faeces were used). Excysted tr...

Arthos J.; Deen K.C.; Chaikin M.A.; Fornwald J.A.; Sathe G.; Sattentau Q.J.; Clapham P.R.; Weiss R.A.; Mcdougal J.S.; Et Al, 1989: Identification of the residues in human cd4 critical for the binding of hiv. The CD4 molecule is a T cell surface glycoprotein that interacts with high affinity with the envelope glycoprotein of the human immunodeficiency virus, HIV, thus serving as a cellular receptor for this virus. To define the sites on CD4 essential f...

Richter-Hintz, D.; Their, R.; Steinwachs, S.; Kronenberg, S.; Fritsche, E.; Sachs, B.; Wulferink, M.; Tonn, T.; Esser, C., 2003: Allelic variants of drug metabolizing enzymes as risk factors in psoriasis. The onset or exacerbation of psoriasis, a T-cell-dependent skin disease with autoimmune features, can be triggered by drugs such as antimalarials and beta-blockers. Xenobiotics may also play a role in idiopathic psoriasis. It has been hypothesized...

Vanhee, Dominique; Joseph, Michel; Vorng, Han; Tonnel, Andre Bernard, 1993: A colorimetric assay to evaluate the immune reactivity of blood platelets based on the reduction of a tetrazolium salt. Since the first report in 1983, blood platelet reactivity from patients with immediate hypersensitivity reactions, and particularly allergic asthma and aspirin-sensitive asthma, has been evaluated by the release of cytotoxic mediators able to indu...

Olvera-Posada, D.; García-Mora, A.; Culebro-García, C.; Castillejos-Molina, R.; Sotomayor, M.; Feria-Bernal, G.; Rodríguez-Covarrubias, F., 2013: Prognostic factors in emphysematous pyelonephritis. The purpose of this study is to analyze our experience with 18 cases of Emphysematous pyelonephritis (EPN) in a tertiary care center and describe our treatment strategy. Of 262 patients admitted with acute pyelonephritis, 18 had CT findings of EPN...

Whiteside, M.; Quan, N.; Wang, X.; Herkenham, M., 1996: Inducible cyclooxygenase mRNA expression in rat brain following peripheral administration of lipopolysaccharide. Society for Neuroscience Abstracts 22(1-3): 87

Hein L.; Ammer K.; Rathkolb O.; Krcevsky N., 1987: Physiotherapy in herpes zoster infection report of a pilot study using low frequency electrotherapy. Standard methods employed in physiotherapy are seldom applied to florid herpes zoster since they bring little benefit. Initial experience with electrotherapy for herpes is reported. Pulsed galvanic current at a frequency of 30 hertz was applied to...

Seeger, T.; Zinsmeister, H. D.; Geiger, H., 1990: The biflavonoid pattern of rhytidiadelphus squarrosus hedw. warnst. From Rhytidiadelphus squarrosus the higherto unknown biflavone 5'-hydroxyrobustaflavone and the three known biflavonoids 5'-hydroxyamentoflavone,5',3"'-dihydroxyamentoflavone and 2,3-dihydro-5'-hydroxyamentoflavone ha...