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Complete sequence of genome of hepatitis B virus precore stop codon variant isolated from a Chinese patient with fulminant hepatitis



Complete sequence of genome of hepatitis B virus precore stop codon variant isolated from a Chinese patient with fulminant hepatitis



Virologica Sinica 12(3): 219-223



The sequence of entire hepatitis B virus (HBV) genome from one Chinese patient with fulminant hepatitis and also from a hepatitis B e antigen (HBeAg) positive carrier from the same region was determined using direct sequencing of amplified viral DNA. The fulminant case was infected with the precore stop codon variant. Compared the sequence from this fulminant case with sequences from fulminant isolate previously reported and also from HBeAg positive carrier from the same region, the results showed significant genetic variations throughout the HBV genome in the precore stop variant sequence and less in the wild type. The increase of variability in the core region in fulminant cases in the Far East origin was found: codon 84apprx97 showing high rates of changes. A clustered mutations previously described in the X region (126apprx132) in sequences reported in Japanese patients and encompassing the enhancer II-core promoter region were not found in the isolate. This study firstly characterized a Chinese fulminant isolate which has some rare and unique changes compared with previously reported isolate from fulminant case.

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