Continuous Fick cardiac output measurement during exercise by monitoring of mixed venous oxygen saturation and oxygen uptake

Nakanishi, N.; Yoshioka, T.; Okano, Y.; Nishimura, T.

Chest 104(2): 419-426


ISSN/ISBN: 0012-3692
PMID: 8339630
DOI: 10.1378/chest.104.2.419
Accession: 008381188

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To determine whether continuous Fick cardiac output measurement is applicable to exercise testing, cardiac output data obtained by the continuous Fick method (Qcf) during exercise were compared with data obtained by the thermodilution method (Qth). Seventeen patients with old myocardial infarction underwent a 1-min or 3-min incremental exercise test (protocols 1 and 2, respectively). During exercise, the oxygen consumption ( ovrhdot VO-2), arterial oxygen saturation (SaO-2), and mixed venous oxygen saturation (S hivin vO-2) were monitored continuously. Qcf was calculated at 12-s intervals by the Fick equation. The SaO-2 remained almost constant during exercise. The S hivin vO-2 showed four characteristic phases during exercise protocol 1. S hivin vO-2 values changed rapidly in phases 2 and 4, but only slightly during phase 3. In exercise protocol 2, S hivin vO-2 almost reached a steady-state by the end of each stage. The correlation between Qcf and Qth was good in protocol 1 (r=0.86), except in phases 2 and 4, and was also good in protocol 2 (r=0.80). We conclude that the continuous Fick method may be applicable for determining the cardiac output during exercise provided that the variation in S hivin vO-2 is slight.