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Conversion of forskolin-insensitive to forskolin-sensitive (mouse-type IX) adenylyl cyclase

Conversion of forskolin-insensitive to forskolin-sensitive (mouse-type IX) adenylyl cyclase

Molecular Pharmacology 53(2): 182-187

Forskolin potently activates all cloned mammalian adenylyl cyclases except type IX by interacting with two homologous cytoplasmic domains (C1 and C2) that form the catalytic core. A mutational analysis of the IIC2 protein (C2 domain from type II adenylyl cyclase) and forskolin analogs suggests that Ser942 interacts with the 7-acetyl group of forskolin.

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Accession: 008388083

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PMID: 9463474

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