+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Cyclosporin A retention enemas in refractory distal ulcerative colitis and pouchitis



Cyclosporin A retention enemas in refractory distal ulcerative colitis and pouchitis



Scandinavian Journal of Gastroenterology 28(8): 701-704



The aim of this study was to evaluate the use of cyclosporin enemas in patients with distal ulcerative colitis and 'pouchitis' resistant to all conventional medical therapy. In an open trial 12 patients with distal ulcerative colitis unresponsive to treatment with topical and oral corticosteroids, 5-aminosalicylic acid, and oral immunosuppressive therapy together with 1 patient with 'pouchitis' unresponsive to repeated courses of antibiotics, topical corticosteroids, and oral mesalazine received 250 mg cyclosporin administered daily as a retention enema. Changes in symptoms and the sigmoidoscopic/histologic appearances of the rectal mucosa were assessed at monthly intervals. Seven of 12 patients with ulcerative colitis improved. There was a strong correlation between clinical and histologic improvement (p lt 0.005). Four of 12 patients showed no response. Three of these required colectomy, two of whom had more extensive disease than had previously been documented. The patient with pouchitis showed improvement in symptoms and 'pouchoscopy' appearance but not in histologic score. Cyclosporin blood concentrations were very low and side effects negligible. Cyclosporin A retention enemas are safe and may be useful in the treatment of severe refractory distal ulcerative colitis. A controlled trial would now seem warranted.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008407756

Download citation: RISBibTeXText

PMID: 8210986

DOI: 10.3109/00365529309098276


Related references

Cyclosporin a retention enemas in refractory distal ulcerative colitis an open trial. Gastroenterology 102(4 Part 2): A947, 1992

Use of cyclosporin retention enemas in a patient with intractable pouchitis after proctocolectomy for ulcerative colitis: a case report. Techniques in Coloproctology 3(1): 43-45, 1999

Treatment of refractory ulcerative colitis with cyclosporin enemas. Lancet 1(8640): 721-722, 1989

Refractory distal ulcerative colitis responsive to 5-aminosalicylate enemas. American Journal of Gastroenterology 80(8): 612-614, 1985

5-ASA enemas for refractory distal ulcerative colitis. An open trial. Journal of Clinical Gastroenterology 9(5): 536-540, 1987

Budesonide versus prednisolone retention enemas in active distal ulcerative colitis. Alimentary Pharmacology and Therapeutics 8(6): 623-629, 1994

The use of cyclosporin retention enemas for pouchitis. Colorectal Disease 1(1): 49, 1999

Butyrate enemas in the treatment of refractory distal ulcerative colitis an open label trial. Gastroenterology 102(2 Part 2): A700, 1992

5-Aminosalicylic acid enemas in refractory distal ulcerative colitis: a randomized, controlled trial. American Journal of Gastroenterology 81(6): 412-418, 1986

5-Aminosalicylic acid enemas in refractory distal ulcerative colitis: long-term results. American Journal of Gastroenterology 82(8): 732-737, 1987

Treatment of refractory distal ulcerative colitis with short chain fatty acid enemas. American Journal of Gastroenterology 91(4): 731-734, 1996

Refractory distal ulcerative colitis response to therapy with 5 amino salicylic acid enemas. Gastroenterologypart 2: 1230, 1984

5 aminosalicylic acid or sulfasalazine retention enemas in distal ulcerative colitis a randomized therapeutic trial. Current Therapeutic Research 42(5): 910-915, 1987

Long term management of refractory distal ulcerative colitis uc with 5 aminosalicylic acid 5 asa enemas late results. Gastroenterology 94(5 Part 2): A483, 1988

A controlled randomized trial of budesonide versus prednisolone retention enemas in active distal ulcerative colitis. Scandinavian Journal of Gastroenterology 22(8): 987-992, 1987