DNA fingerprinting by hybridisation to oligonucleotide arrays
Electrophoresis 16(9): 1539-1542
ISSN/ISBN: 0173-0835 PMID: 8582332 DOI: 10.1002/elps.11501601256
Most methods for analyzing variation in DNA sequences rely on gel electrophoresis, a method which is difficult to automate and to quantify. Hybridization to oligonucleotides bound to a solid surface offers alternatives, with the advantage that they can be more readily automated and lend themselves to powerful statistical analytical procedures. In this paper, we discuss a number of different ways in which oligonucleotide arrays could be used for DNA typing for applications in forensic science.