+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Delayed-type hypersensitivity to cow's milk protein in Melkersson-Rosenthal syndrome: coincidence or pathogenetic role?



Delayed-type hypersensitivity to cow's milk protein in Melkersson-Rosenthal syndrome: coincidence or pathogenetic role?



Dermatology 192(2): 99-102



Background: Intolerance to cow's milk protein is frequently seen in children and rarely in adults. Non-IgE-mediated hypersensitivity to cow's milk protein has been suspected in children based on in vitro evidence. Food intolerance may play a pathogenetic role in some cases of Melkersson-Rosenthal syndrome, which is often of unknown origin. Objective: We describe an adult female patient who developed a Melkersson-Rosenthal syndrome and at the same time was found to have in vivo and in vitro evidence of a delayed-type hypersensitivity to cow's milk protein. Methods: Allergic and immunologic examinations, including skin prick tests, patch tests, serology, lymphocyte transformation tests and biopsies were performed. Results: A positive patch test to alpha-lactalbumin, a positive lymphocyte transformation test to whole cow's milk and an immunohistology with infiltration of CD4+ and CD8+ T cells were found. Conclusions: There is a possible pathogenetic relation between delayed-type hypersensitivity to cow's milk protein and Melkersson-Rosenthal syndrome in the patient presented.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 008426810

Download citation: RISBibTeXText

PMID: 8829519


Related references

Delayed-Type Hypersensitivity to Cow’s Milk Protein in Melkersson-Rosenthal Syndrome: Coincidence or Pathogenetic Role?. Dermatology 192(2): 99-102, 1996

The Melkersson-Rosenthal syndrome and food additive hypersensitivity. British Journal of Dermatology 131(6): 921-922, 1994

Melkersson-Rosenthal syndrome: the possible role of co-morbidities in the etiopathogenesis. Giornale Italiano di Dermatologia E Venereologia 2018, 2018

Role of recurrent oral candidiasis associated with lingua plicata in the Melkersson-Rosenthal syndrome. British Journal of Dermatology 132(2): 311-312, 1995

Regulation of delayed-type hypersensitivity. VII. The role of I-J subregion gene products in the inhibition of delayed-type hypersensitivity to major histocompatibility antigens by specific suppressor T cells. European Journal of Immunology 11(11): 883-888, 1981

Melkersson rosenthal syndrome. Archives of Otolaryngology Head & Neck Surgery 116(6): 728-729, 1990

Melkersson-Rosenthal Syndrome. Archives of Otolaryngology - Head and Neck Surgery 116(6): 728-729, 1990

Melkersson-Rosenthal syndrome. International Journal of Oral & Maxillofacial Surgery 21(2): 115-117, 1992

Melkersson-Rosenthal Syndrome. International Journal of Dermatology 24(1): 456-457, 1985

Melkersson-Rosenthal syndrome. Qjm 111(3): 199, 2017

Melkersson - Rosenthal Syndrome. Indian Journal of Dermatology, Venereology and Leprology 46(3): 184-186, 1980

Melkersson Rosenthal Syndrome. Indian Journal of Dermatology, Venereology and Leprology 45(5): 360-367, 1979

Melkersson-Rosenthal syndrome. Journal of Laryngology & Otology 116(5): 386-388, 2002

Melkersson-Rosenthal Syndrome. Seminars in Dermatology 14(2): 135-139, 1995

On the Melkersson-Rosenthal Syndrome. Vestnik Dermatologii i Venerologii 37: 69-70, 1963