+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Depletion of penicillin G residues in tissues and injection sites of yearling beef steers dosed with benzathine penicillin G alone or in combination with procaine penicillin G



Depletion of penicillin G residues in tissues and injection sites of yearling beef steers dosed with benzathine penicillin G alone or in combination with procaine penicillin G



Food Additives and Contaminants 11(1): 1-6



The contribution of benzathine penicillin G to residues in tissues and injection sites of yearling beef steers was assessed by treating seven groups of five to seven steers with either benzathine and procaine penicillin G together or benzathine penicillin G alone. Steers were injected with a commercial combination of benzathine and procaine penicillin G according to the Canadian (intramuscular) or United States (subcutaneous) label dosages of 8600 and 8800 IU penicillin G/kg body weight, respectively. They were killed 14 or 30 days after the intramuscular injections, and 30 days after the subcutaneous injections. At the label withdrawal times, Canadian 14 days and United States 30 days, the levels in the injection sites for all of the treatments were 30-60 times above the Canadian and United States' Maximum Residue Limit of 50 micrograms/kg, while liver, kidney and gluteal muscle levels were below the Maximum Residue Limit. Other steers were injected intramuscularly with 24,000 IU benzathine/procaine penicillin G/kg body weight and slaughtered 8, 14 or 50 days after injection. Fifty-day injection site residues were 24 times the Maximum Residue Limit. Another group of steers was injected intramuscularly with benzathine penicillin G alone at 12,000 IU/kg body weight and slaughtered 14 days later. Penicillin G levels in the injection sites were 156 times the Maximum Residue Limit. The persistence of penicillin G residues at the injection sites in all the treatment groups appears to be attributable primarily to benzathine penicillin G. Visual inspection of muscle surfaces did not reliably reveal all injection site lesions in the underlying musculature.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008430923

Download citation: RISBibTeXText

PMID: 8181627

DOI: 10.1080/02652039409374196


Related references

Depletion of penicillin G residues in tissues, plasma and injection sites of market pigs injected intramuscularly with procaine penicillin G. Food Additives and Contaminants 15(4): 421-426, 1998

Disposition of penicillin G after administration of benzathine penicillin G, or a combination of benzathine penicillin G and procaine penicillin G in cattle. American Journal of Veterinary Research 55(6): 825-830, 1994

Depletion of intramuscularly and subcutaneously injected procaine penicillin G from tissues and plasma of yearling beef steers. Canadian Journal of Veterinary Research 57(4): 223-230, 1993

Body fluid concentrations of penicillin following intramuscular injection of single doses of benzathine penicillin G and/or procaine penicillin G. Antibiotic Medicine and Clinical Therapy 6(4): 232-241, 1959

Penicillin blood levels in pigs after subcutaneous injection of procaine penicillin, benzathine penicillin and Penatrit.. Med. Wet 18: 654-658, 1962

Serum concentration of penicillin in the horse after repeated intramuscular injections of procaine penicillin G alone or in combination with benzathine penicillin and/or phenylbutazone. American Journal of Veterinary Research 45(5): 1003-1007, 1984

Soluble penicillin & relatively insoluble derivatives: sodium penicillin G, procaine penicillin G & benzathine penicillin G; pharmacological & therapeutic considerations. La Semana Medica 110(4): 115-122, 1957

Oral administration of penicillin; a comparative study of benzathine penicillin, procaine penicillin and potassium penicillin. Acta Pharmacologica et Toxicologica 11(1): 49-54, 1955

Procaine penicillin and interrupted penicillin treatment in Streptococcus agalactiae mastitis I. Procaine penicillin in the bovine udder. II. Therapy studies with procaine penicillin and calcium penicillin. Vet Rec 62(2): 11-14, 1950

Application of a spectrophotometric method to the determination of potassium penicillin, procaine penicillin and benzathine penicillin in pharmaceutical preparations. Journal of Pharmacy and Pharmacology 10(12): 762-769, 1958

Benzathine penicillin G and procaine penicillin G in piglets: comparison of intramuscular and subcutaneous injection. Veterinary Research Communications 26(6): 459-465, 2002

Concentration of penicillin in the blood of sheep after injection of crystalline, procaine or benzathine penicillin.. Med. Wet 18: 14-17, 1962

Oral Administration of Penicillin. A Comparative Study of Benzathine Penicillin, Procaine Penicillin and Potassium Penieillin. Basic and Clinical Pharmacology and Toxicology 11(1): 49-54, 1955

Benzathine penicillin G, alone and in combination with procaine penicillin, in outpatient treatment of medically indigent children with acute respiratory infections. Antibiotic Medicine and Clinical Therapy 4(6): 333-342, 1957

Injection site residues of benzathine/procaine penicillin G. Canadian Veterinary Journal 33(12): 773-774, 1992