+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Developmental effects of fumonisin B1-containing Fusarium moniliforme culture extract in CD1 mice



Developmental effects of fumonisin B1-containing Fusarium moniliforme culture extract in CD1 mice



Mycopathologia 128(2): 111-118



Pregnant Charles River CD1 mice were treated with a semipurified extract of Fusarium moniliforme culture containing 0, 12.5, 25, 50 or 100 mg FB-1/kg each day orally (diluted in distilled water) between gestational days (GD) 7 and 15 to evaluate the developmental toxicity of FB-1. Following sacrifice of dams on GD 18, litters were examined for gross abnormalities and divided equally for skeletal or visceral examination by routine techniques. Significant maternal mortality was observed at doses of 50 and 100 mg FB-1/kg. Dose-dependant decreases in maternal body weight gains, number of live offsprings per litter, and mean body weight of the offspring were produced at FB-1 doses of 25 mg/kg or higher. The percentage of implants resorbed increased at all doses in a dosedependant manner. A dose-dependant increase, except at the lowest dose tested, in the incidence of ossification deficits involving digits and stemum, short and wavy ribs, and hydrocephalus of lateral and third ventricles was also evident. Cleft palate was seen only at the highest FB-1 dose. Maternal intoxication manifested as a dose-dependant increase in the severity of ascites associated mainly with increased histopathologic scores reflecting hepatocellular damage at day 18. Concommittant increases in serum alanine amino transferase (ALT) on GD 12, reflecting parenchymal liver cell damage, was also observed at all doses above 12.5 mg of FB-1/kg. These results suggest that FB-1-containing F. moniliforme culture extract is developmentally toxic in mice, and that this toxicity may be mediated by maternal hepatotoxicity.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 008456715

Download citation: RISBibTeXText

PMID: 7777035


Related references

Developmental toxicity in hamsters of an aqueous extract of Fusarium moniliforme culture material containing known quantities of fumonisin B1. Veterinary and Human Toxicology 36(1): 5, 1994

Individual and combined effects of feeding fumonisin B-1 and moniliformin, supplied by Fusarium moniliforme and Fusarium fujikuroi culture material, in the young broiler chick. Poultry Science 73(Suppl. 1): 99, 1994

Effects of Fusarium moniliforme culture material containing known levels of fumonisin B1 in ducklings. Avian Diseases 39(4): 879-886, 1995

The chronic effects of Fusarium moniliforme culture material, containing known levels of fumonisin B1, in turkeys. Avian Diseases 40(1): 231-235, 1996

Effects of fumonisin B, present in Fusarium moniliforme culture material, in broiler chicks. Poultry Science 72(Suppl. 1): 176, 1993

Effects of fusarium moniliforme culture material containing known levels of fumonisin b 1 on turkey poults. Poultry Science 71(Suppl. 1): 162, 1992

Effects of fumonisin B-1, present in Fusarium moniliforme culture material in turkey poults. Poultry Science 72(Suppl. 1): 197, 1993

Subchronic toxic effects of Fusarium moniliforme and fumonisin B1 in rats and mice. Natural Toxins 4(1): 16-23, 1996

Effects of feeding Fusarium verticillioides (formerly Fusarium moniliforme) culture material containing known levels of fumonisin B1 in Japanese quail (Coturnix coturnix japonica). Poultry Science 85(7): 1129-1135, 2006

Long-term effects of feeding laying hens diets containing moniliformin present in Fusarium fujikuroi culture material and fumonisin present in Fusarium moniliforme culture material. Poultry Science 76(Suppl. 1): 3, 1997

Effects of long-term feeding of diets containing moniliformin, supplied by Fusarium fujikuroi culture material, and fumonisin, supplied by Fusarium moniliforme culture material, to laying hens. Poultry Science 78(11): 1499-1505, 1999

Individual and combined effects of moniliformin present in Fusarium fujikuroi culture material and fumonisin present in Fusarium moniliforme culture material in layer hens. Poultry Science 75(Suppl. 1): 126, 1996

Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick. Poultry Science 72(3): 456-466, 1993

Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, in the young turkey poult. Poultry Science 75(12): 1472-1478, 1996

Toxicological effects of chronic low doses of aflatoxin B1 and fumonisin B1-containing Fusarium moniliforme culture material in weaned piglets. Food and Chemical Toxicology 41(10): 1345-1353, 2003