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Diastereo-differentiating coupling of phenoxy radical moiety controlled by 2,4-pentanediol tether: Preparation of optically active Pummerer's ketone analogs

Yamaguchi, K.; Sugimura, T.; Nishida, F.; Tai, A.

Tetrahedron Letters 39(25): 4521-4524

1998


ISSN/ISBN: 0040-4039
DOI: 10.1016/s0040-4039(98)00805-3
Accession: 008462269

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The highly diastereo-differentiating coupling of the phenoxy radical could be achieved by a 2,4-pentanediol tethered reaction to give a single diastereomer of Pummerer's ketone analog. By the removal of the chiral auxiliary, the optically active phenoxy radical dimer was obtained in good yield.

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