+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Differences in the distribution of acidic mucins between flat tubular adenomas and flat serrated adenomas of the colorectal mucosa



Differences in the distribution of acidic mucins between flat tubular adenomas and flat serrated adenomas of the colorectal mucosa



In Vivo 10(3): 383-388



Two consecutive sections from 72 endoscopically detected flat colorectal polyps (flat tubular adenomas n = 40, flat serrated adenomas n = 18, flat hyperplastic polyps n = 7 and normal colonic mucosa n = 7) were stained with Alcian blue pH 2.5 (AB) or with high iron diamine (HID) without counterstain, to evidence the most important attribute of the colorectal cells i.e. their capacity to produce acidic mucins (sialomucins and sulphomucins respectively). Intense AB and HID staining (++) was found in the upper part of the crypts of all (100%) sections with normal colonic mucosa or with flat hyperplastic polyps, in 13 of the 18 (72%) flat serrated adenomas (with low grade dysplasia = LGD, n = 16; or high grade dysplasia = HGD, n = 2) but in none (0%) of the 40 tubular adenomas. Slight (+) or negative staining of the upper part of the crypts were recorded in all 40 (100%) flat tubular adenomas (LGD n = 32; HGD, n = 8), but in only 5 of the 18 (27,7%) flat serrated adenomas (LGD n = 3; HGD n = 2) and in none (0%) of the sections with normal colonic mucosa or with flat hyperplastic polyps. Intense AB and HID staining (++) was found in the lower part of the crypts in all sections (100%) with normal mucosa or with flat hyperplastic polyps, in 36 of the 40 flat (90%) tubular adenomas (LGD n = 32; HGD n = 8), but in none (0%) of the flat serrated adenomas. Slight (+) or negative stainings in the lower part of the crypts were recorded in all 18 (100%) flat serrated adenomas, but in only 4 of the 40 (10%) flat tubular adenomas and in none of the sections (0%) with normal mucosa or with flat hyperplastic polyps. Thus, the mucosal localization of the depletion of mucin production differs in flat serrated adenomas and in flat tubular adenomas. The difference in topographic distribution of the depletion of acidic mucins in epithelial cells is a new argument in favour of the identity of flat serrated adenomas as an independent neoplastic phenotype in the colorectal mucosa.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 008467017

Download citation: RISBibTeXText

PMID: 8797044


Related references

Flat serrated adenomas and flat tubular adenomas of the colorectal mucosa: differences in the pattern of cell proliferation. Japanese Journal of Cancer Research 86(8): 756-760, 1995

P53 overexpression in flat serrated adenomas and flat tubular adenomas of the colorectal mucosa. Journal Of Cancer Research & Clinical Oncology. 121(9-10): 571-576, 1995

Flat serrated adenomas of the colorectal mucosa. Japanese Journal Of Cancer Research. 87(3): 305-309, 1996

Flat serrated adenomas of the colorectal mucosa in Japanese patients. In Vivo 10(3): 339-343, 1996

Flat adenomas and flat adenocarcinomas of the colorectal mucosa in Japanese and Swedish patients. Diseases of the Colon & Rectum 38(10): 1075-1079, 1995

Flat adenomas and flat adenocarcinomas of the colorectal mucosa in Japanese and Swedish patients. Comparative histologic study. Diseases of the Colon and Rectum 38(10): 1075-1079, 1995

Small flat adenomas and flat adenocarcinomas of the colorectal mucosa in Swedish and Japanese patients A comparative histological study. Pathology Research & Practice 191(7-8): 765-766, 1995

Differences in angiogenesis and collagenesis between exophytic and flat adenomas of the colorectal mucosa. Anticancer Research 17(1b): 737-742, 1997

MUC1 and MUC2 mucins in flat and polypoid colorectal adenomas. Journal of Clinical Pathology 50(5): 417-421, 1997

"Are we ready to change our colorectal cancer screening practice?" Traditional serrated adenomas or serrated adenomas with dysplasia should be regarded as advanced adenomas with high grade dysplasia. Turkish Journal of Gastroenterology 27(5): 482-483, 2016

GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features. Histopathology 70(7): 1079-1088, 2017

Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas. Japanese Journal Of Cancer Research. 85(2): 147-151, 1994

An update on colorectal cancer pathology flat mucosal markers and flat adenomas in the lynch syndromes. Journal of Tumor Marker Oncology 5(3): 205, 1990

Enhanced apoptosis in flat adenomas of the colorectal mucosa in Swedish and Japanese patients. Pathology Research & Practice 191(7-8): 766, 1995

Are there any differences in colorectal cancer risk between polypoid and flat adenomas?. Gastroenterology 112(4 SUPPL ): A584, 1997