+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Differential effects of insulin-induced hypoglycaemia on the plasma branched-chain and non-branched-chain amino acid concentrations in humans



Differential effects of insulin-induced hypoglycaemia on the plasma branched-chain and non-branched-chain amino acid concentrations in humans



Diabete and Metabolisme 18(4): 277-282



In order to determine plasma amino acid concentrations during a prolonged but moderate insulin-induced hypoglycemia, six healthy volunteers received a constant subcutaneous insulin infusion (15 mU cntdot m-2 cntdot min-1) over a 12 hour period. The plasma glucose concentrations decreased from 4.72 +- 0.11 to 2.83 +- 0.07 mM at 600 minutes and then remained stable over the last 120 minutes. Plasma counterregulatory hormones (glucagon, epinephrine, growth hormone and cortisol) increased significantly between 120 and 180 minutes. The plasma concentration of all the amino acids paralleled the decrease in plasma glucose. The branched chain amino acids decreased to a greater extent in the first part of the study (0-360 min) in comparison to the essential non-branched chain aminoacids (p lt 0.01), then increased significantly with a peak at 600 minutes (p lt 0.05 vs 360 min) despite stable hyperinsulinemia. These results suggests that during prolonged but moderate hypoglycemia the counterregulatory hormones are able to antagonize partially the effects of insulin on protein metabolism, analogous to their well-known anti-insulin effects on glucose and fatty acid metabolism.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 008471082

Download citation: RISBibTeXText

PMID: 1459315


Related references

Interactions among the branched-chain amino acids and their effects on methionine utilization in growing pigs: effects on plasma amino- and keto-acid concentrations and branched-chain keto-acid dehydrogenase activity. British Journal of Nutrition 83(1): 49-58, 2000

Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 3. effects of administration of short chain fatty acid on blood branched chain amino acid concentrations in rats. Acta Scholae Medicinalis Universitatis in Gifu 29(4): 642-651, 1981

Divergent Induction of Branched-Chain Aminotransferases and Phosphorylation of Branched Chain Keto-Acid Dehydrogenase Is a Potential Mechanism Coupling Branched-Chain Keto-Acid-Mediated-Astrocyte Activation to Branched-Chain Amino Acid Depletion-Mediated Cognitive Deficit after Traumatic Brain Injury. Journal of Neurotrauma 35(20): 2482-2494, 2018

Mechanism of decreases in blood branched chain amino acid levels in liver cirrhosis 2. effects of administration of ammonia on blood branched chain amino acid concentrations in rats. Acta Scholae Medicinalis Universitatis in Gifu 29(4): 630-641, 1981

Branched-chain amino acid catabolism rather than amino acids plasma concentrations is associated with diet-induced changes in insulin resistance in overweight to obese individuals. Nutrition Metabolism and Cardiovascular Diseases 27(10): 858-864, 2017

Effects of branched-chain amino acid supplementation on plasma concentrations of free amino acids, insulin, and energy substrates in young men. Journal of Nutritional Science and Vitaminology 57(1): 114-117, 2011

The effects of plasma insulin and branched chain amino acid concentrations on blood brain barrier amino acid transport following porta caval shunt. Gastroenterology 75(5): 969, 1978

High branched-chain a-keto acid intake, branched-chain a-keto acid dehydrogenase activity, and plasma and brain amino acid and plasma keto acid concentrations in rats. The American Journal of Clinical Nutrition 52: 3-19, 1990

Correlation between serum concentrations of the branched chain amino- and alpha-keto-acid and the distribution of the branched-chain fatty acids on rat skin surface. Journal of Nutritional Science and Vitaminology 37(3): 297-311, 1991

Effects of acute exposure to increased plasma branched-chain amino acid concentrations on insulin-mediated plasma glucose turnover in healthy young subjects. Plos one 10(3): E0120049, 2015

High branched-chain alpha-keto acid intake, branched-chain alpha-keto acid dehydrogenase activity, and plasma and brain amino acid and plasma keto acid concentrations in rats. American Journal of Clinical Nutrition 52(2): 313-319, 1990

Regulation of taste-active components of meat by dietary branched-chain amino acids; effects of branched-chain amino acid antagonism. British Poultry Science 49(3): 299-307, 2008

Lowered concentrations of branched-chain amino acids result in impaired growth and neurological problems: insights from a branched-chain alpha-keto acid dehydrogenase complex kinase-deficient mouse model. Nutrition Reviews 65(4): 167-172, 2007

Regulation of branched-chain amino acid metabolism and pharmacological effects of branched-chain amino acids. Hepatology Research 30s: 3-8, 2004

Short-Term Effects of Branched-Chain Amino Acids-Enriched Dialysis Fluid on Branched-Chain Amino Acids Plasma Level and Mass Balance: A Randomized Cross-Over Study. Journal of Renal Nutrition 2019:, 2019