+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein

Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein

Proceedings of the National Academy of Sciences of the United States of America 90(12): 5404-5408

Leukocyte tyrosine kinase (LTK) is a tyrosine kinase that has been suggested to be specific for hematopoietic cells and neuronal cells and reported as an unusual membrane protein lacking an extracellular domain. Here we report the cloning of a human LTK cDNA clone containing the complete open reading frame of a putative receptor tyrosine kinase protein. The extracellular domain of the receptor protein is larger than previously predicted. Furthermore, we have cloned a set of cDNAs representing differently spliced human LTK mRNAs. These cDNAs predict a truncated receptor protein lacking the tyrosine kinase domain and a soluble receptor protein that has neither a transmembrane nor a tyrosine kinase domain. Our results suggest that the LTK gene produces not only the putative receptor tyrosine kinase for unknown ligand but also multiple protein products that may have different functions.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 008477025

Download citation: RISBibTeXText

PMID: 7685902

DOI: 10.2307/2362405

Related references

Alternatively spliced juxtamembrane domain of a tyrosine kinase receptor is a multifunctional regulatory site. Deletion alters cellular tyrosine phosphorylation pattern and facilitates binding of phosphatidylinositol-3-OH kinase to the hepatocyte growth factor receptor. Journal of Biological Chemistry 270(2): 507-510, 1995

Substitution of glutamic acid for alanine-1135 in the putative catalytic loop of the tyrosine kinase domain of the human insulin receptor: A mutation that impairs proteolytic processing into subunits and inhibits receptor tyrosine kinase activity. Journal of Biological Chemistry 268(11): 8060-8069, 1993

Kaposi's sarcoma-associated herpesvirus-encoded G protein-coupled receptor activation of c-jun amino-terminal kinase/stress-activated protein kinase and lyn kinase is mediated by related adhesion focal tyrosine kinase/proline-rich tyrosine kinase 2. Journal of Biological Chemistry 274(45): 31863-7, 1999

The 38-amino-acid form of pituitary adenylate cyclase-activating polypeptide induces neurite outgrowth in PC12 cells that is dependent on protein kinase C and extracellular signal-regulated kinase but not on protein kinase A, nerve growth factor receptor tyrosine kinase, p21(ras) G protein, and pp60(c-src) cytoplasmic tyrosine kinase. Molecular Pharmacology 54(3): 547-558, 1998

The first structure of a receptor tyrosine kinase domain A further step in understanding the molecular basis of insulin action Both the observed cis-inhibition and the proposed trans-activation of the insulin receptor tyrosine kinase help explain insulin signalling through its receptor. Structure 3(1): 1-6, 1995

Anaplastic Lymphoma Kinase Is Activated Through the Pleiotrophin/Receptor Protein-tyrosine Phosphatase b/z Signaling Pathway. An Alternative Mechanism of Receptor Tyrosine Kinase Activation. The Journal of Biological Chemistry 282(39): 683-90, 2007

Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation. Journal of Biological Chemistry 282(39): 28683-28690, 2007

Role of tyrosine kinase Csk in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration. Journal of Biological Chemistry 281(15): 10583-8, 2006

Signal transduction through a bimolecular receptor tyrosine protein kinase composed of a platelet-derived growth factor receptor-CD4 chimera and the nonreceptor tyrosine protein kinase Lck. Journal of Biological Chemistry 268(26): 19882-19888, 1993

Protein tyrosine kinase inhibitor geldanamycin effectively blocks ligand induced receptor protein tyrosine kinase activation and rapidly down-modulates HER-2/NEU receptor expression in breast cancer cell lines. Onkologie 18(Suppl. 2): 104, 1995

Importance of Asp1191 for tyrosine kinase activity of the insulin receptor: functional difference of universally conserved Asp between tyrosine kinase and c-AMP dependent serine/threonine protein kinase. Biochemical and Biophysical Research Communications 197(2): 353-359, 1993

JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia. Molecular Cancer Therapeutics 8(11): 3151-3161, 2009

Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase. Journal of Biological Chemistry 271(44): 27707-27714, 1996

ALK, the chromosome 2 locus altered by the t in non-Hodgkins lymphoma , encodes a neural-specific receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase. Blood 86(10 Suppl. 1): 165A, 1995

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 14(18): 2175-2188, 1997