Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells, and IL-2 and IL-6 production
Reinhold, D.; Bank, U.; Bühling, F.; Neubert, K.; Mattern, T.; Ulmer, A.J.; Flad, H.D.; Ansorge, S.
Immunobiology 188(4-5): 403-414
1993
ISSN/ISBN: 0171-2985 PMID: 7902330 DOI: 10.1016/s0171-2985(11)80223-8
Accession: 008479553
In the present report, we describe that synthetic inhibitors of and polyclonal and monoclonal antibodies against the membrane ectoenzyme dipeptidyl peptidase IV (DP IV, CD26) inhibit the production of IL-2 and IL-6 and, concomitantly, DNA synthesis of pokeweed mitogen-stimulated peripheral blood mononuclear cells (PBMC). The release of IL-1 and TNF-alpha, was not influenced under these conditions. The data support the hypothesis that DP IV, possibly in conjunction with other peptidase, is involved in the regulation of activation and proliferation of T lymphocytes.