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Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1)


Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1)



Journal of Biological Chemistry 270(20): 11757-11760



ISSN/ISBN: 0021-9258

PMID: 7744823

DOI: 10.1074/jbc.270.20.11757

Mitogen-activated protein kinase kinase kinase (MEKK1) is a serine-threonine kinase that regulates sequential protein kinase pathways involving stress-activated protein kinases and mitogen-activated protein kinases. MEKK1 is activated in response to growth factor stimulation of cells and by expression of activated Ras. We demonstrate that the kinase domain of MEKK1 (MEKK-COOH) binds to GST-Ras-V12 in a GTP-dependent manner.

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Accession: 008479933

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