+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Disposition of Haloperidol and Reduced Haloperidol Plasma Levels After Single Dose Haloperidol Decanoate Administration



Disposition of Haloperidol and Reduced Haloperidol Plasma Levels After Single Dose Haloperidol Decanoate Administration



Human Psychopharmacology. 10(1): 47-51



A single dose of haloperidol decanoate 100 mg was administered to 15 schizophrenic patients. Blood samples were obtained prior to injection, 1 h, 3 h, 6 h, 8 h, 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, one week, two weeks, three weeks and four weeks post-injection. Haloperidol and its reduced metabolite, reduced haloperidol, plasma levels were assayed by HPLC with electrochemical detection. The pharmacokinetic parameters of haloperidol were determined. The mean time of maximal (T-max) plasma levels for haloperidol was 5.73 +- 0.80 days. The haloperidol plasma levels showed a biexponential decline with an elimination half-life of 15.78 +- 5.90 days. Reduced haloperidol was rapidly formed from the haloperidol. The T-max of reduced haloperidol was 7.00 +- 2.35 days. The mean ratio reduced haloperidol/haloperidol was 0.155 +- 0.111. Since the T-max occurs at approximately six days, a weekly loading dose of haloperidol decanoate is feasible during the transition from oral to depot therapy.

(PDF emailed within 0-6 h: $19.90)

Accession: 008485119

Download citation: RISBibTeXText

DOI: 10.1002/hup.470100108


Related references

Haloperidol and reduced haloperidol plasma concentrations after a loading dose regimen with haloperidol decanoate. Progress In Neuro-Psychopharmacology & Biological Psychiatry. 20(1): 73-86, 1996

The plasma haloperidol and reduced haloperidol concentrations in chinese schizophrenic patients: Relationship between reduced haloperidol/haloperidol ratio and red blood cell haloperidol reductase activity. Human Psychopharmacology: Clinical and Experimental 7(2): 123-128, 1992

The plasma haloperidol and reduced haloperidol concentrations in chinese schizophrenic patients relationship between reduced haloperidol haloperidol ratio and red blood cell haloperidol reductase activity. Human Psychopharmacology 7(2): 123-128, 1992

Reduced haloperidol/haloperidol ratios after oral haloperidol and decanoate administration in schizophrenics. Progress in Neuro-Psychopharmacology & Biological Psychiatry 17(1): 105-112, 1993

Simultaneous determination of plasma haloperidol and its metabolite reduced haloperidol by liquid chromatography with electrochemical detection: Plasma levels in schizophrenic patients treated with oral or intramuscular depot haloperidol. Journal of Chromatography B Biomedical Applications 656(2): 373-381, 1994

Prolonged haloperidol and reduced haloperidol plasma concentrations after decanoate withdrawal. Schizophrenia Research 9(1): 35-40, 1993

Schizophrenic patients treated with haloperidol decanoate Clinical evaluations Plasma and red blood cell concentrations of haloperidol and its reduced metabolite. Therapie (Paris) 0(SUPPL ): 241, 1995

Haloperidol plasma 'threshold' levels for relapse prevention in schizophrenia: A study with haloperidol decanoate. European Neuropsychopharmacology 5(SUPPL.): 55-58, 1995

Pharmacoclinical correlations in schizophrenic patients treated with haloperidol decanoate: Clinical evaluations, concentrations of plasma and red blood cell haloperidol and its reduced metabolite, and plasma homovanillic acid. Progress in Neuro Psychopharmacology and Biological Psychiatry 19(7): 1119-1135, 1995

Pharmacokinetics of haloperidol and reduced haloperidol in Chinese schizophrenic patients after intravenous and oral administration of haloperidol. Psychopharmacology 106(4): 517-522, 1992

Plasma reduced haloperidol/haloperidol ratios in schizophrenic patients treated with high dosages of haloperidol. European Neuropsychopharmacology 4(2): 119-126, 1994

The difference of response to a single dose of haloperidol between acute schizophrenic patients and normal controls in respect to plasma levels of haloperidol and prolactin. Folia Psychiatrica et Neurologica Japonica 36(2): 199-200, 1982

Measurement of haloperidol reductase activity in red blood cells and reduced haloperidol to haloperidol ratios in plasma in oriental psychiatric patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry 14(6): 941-948, 1990

Determination of haloperidol and reduced haloperidol in the plasma and blood of patients on depot haloperidol. Psychopharmacology 106(2): 268-274, 1992

Effects of smoking on haloperidol and reduced haloperidol plasma concentrations and haloperidol clearance. Psychopharmacology 90(4): 468-470, 1986