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Divergent effects of ruthenium red and ryanodine on Ca2+/calmodulin-dependent phosphorylation of the Ca2+ release channel (ryanodine receptor) in cardiac sarcoplasmic reticulum



Divergent effects of ruthenium red and ryanodine on Ca2+/calmodulin-dependent phosphorylation of the Ca2+ release channel (ryanodine receptor) in cardiac sarcoplasmic reticulum



Archives of Biochemistry and Biophysics 333(2): 368-376



In cardiac muscle, a Ca-2+/calmodulin-dependent protein kinase (CaM kinase) associated with the sarcoplasmic reticulum (SR) is known to phosphorylate the membrane proteins phospholamban, Ca-2+-ATPase, and Ca-2+-release channel (ryanodine receptor). Phosphorylation of phospholamban and Ca-2+-ATPase is recognized to stimulate Ca-2+2+ sequestration by the SR but the functional consequence of Ca-2+'- channel phosphorylation has not been clearly established.

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Accession: 008494419

Download citation: RISBibTeXText

PMID: 8809075

DOI: 10.1006/abbi.1996.0403


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