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Does captopril scavenge superoxide radical?



Does captopril scavenge superoxide radical?



Medical Science Research 25(12): 841-843



Polymorphnuclear leucocytes were isolated from the blood of healthy donors and were stimulated by calcium ionophore (A23187) for 10 min for the generation of superoxide radical that reduces nitro blue tetrazolium (NBT) into blue formazan. Pre-incubation of human neutrophils with different concentrations of captopril did not inhibit the formation of the formazan. Addition of superoxide dismutase, but not captopril, to in vitro superoxide radical producing systems inhibited the reduction of ferricytochrome C and NBT. These results support the concept that captopril is not a scavenger of superoxide radical in the models studied.

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