+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Does captopril scavenge superoxide radical?

Does captopril scavenge superoxide radical?

Medical Science Research 25(12): 841-843

Polymorphnuclear leucocytes were isolated from the blood of healthy donors and were stimulated by calcium ionophore (A23187) for 10 min for the generation of superoxide radical that reduces nitro blue tetrazolium (NBT) into blue formazan. Pre-incubation of human neutrophils with different concentrations of captopril did not inhibit the formation of the formazan. Addition of superoxide dismutase, but not captopril, to in vitro superoxide radical producing systems inhibited the reduction of ferricytochrome C and NBT. These results support the concept that captopril is not a scavenger of superoxide radical in the models studied.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 008497159

Download citation: RISBibTeXText

Related references

Captopril does not scavenge superoxide captopril prevents superoxide radical production by chelating copper. Archives of Biochemistry & Biophysics 290(2): 463-467, 1991

Captopril does not scavenge superoxide: captopril prevents O2-. production by chelating copper. Archives of Biochemistry and Biophysics 290(2): 463-467, 1991

Captopril and enalaprilat do not scavenge the superoxide anion. American Journal of Cardiology 65(19): 24i-27i, 1990

Effect of captopril cv 3611 coq 10 on myocardial superoxide anion radical generation. Japanese Circulation Journal 53(6): 516, 1989

Changes in the superoxide radical and superoxide dismutase levels in the uterus of Rattus norvegicus during the estrous cycle and a possible role for superoxide radical in uterine oedema and cell proliferation at proestrus. Biochemistry and Cell Biology 69(4): 313-316, 1991

Evaluation of the ability of the angiotensin-converting enzyme inhibitor captopril to scavenge reactive oxygen species. Chemico-Biological Interactions 77(3): 303-314, 1991

Effect of some radical scavenge. Kyushu Daigaku Nogakubu gakugei zasshi = Science bulletin of the Faculty of Agriculture Kyushu University 36(1): 19-24, 1981

Superoxide radical and superoxide dismutase in the free-radical theory of aging (a review). Voprosy Meditsinskoi Khimii 28(4): 8, 1982

Can exogenous oestrogen scavenge superoxide anions in stroke-prone rats?. British Journal of Pharmacology 135(Proceedings Suppl.): 222P, 2002

The PARS inhibitors 3-aminobenzamide, nicotinamide and 1,5-dihydroxyisoquinoline do not scavenge superoxide anions in vitro. British Journal of Pharmacology 124(PROC Suppl. ): 105P, 1998

Relation between pigment gallstone formation and the ability of bile to scavenge superoxide radicals. Zhonghua Yi Xue Za Zhi 73(9): 544-6 575-6, 1993

Respiring mitochondria scavenge extramitochondrial superoxide via a non-enzymatic mechanism A new role for electron transport. Journal of Investigative Medicine 43(Suppl. 2): 247A, 1995

The retinal carotenoids zeaxanthin and lutein scavenge superoxide and hydroxyl radicals: a chemiluminescence and ESR study. Molecular Vision 12: 1127-1135, 2006

The ability of bile to scavenge superoxide radicals and pigment gallstone formation in guinea pigs. Hpb Surgery 10(2): 73, 1996