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Effect of copper and copper binding protein on the CT attenuation value of liver: experimental study in rats



Effect of copper and copper binding protein on the CT attenuation value of liver: experimental study in rats



Nihon Igaku Hoshasen Gakkai Zasshi. Nippon Acta Radiologica 55(3): 190-192



We analyzed the effect of copper and copper binding protein on CT attenuation value in a rat model. CT attenuation values of the liver were compared with hepatic copper content and grade of orcein-positive granules, which are thought to be a counterpart of polymerized methalothionein in lysosomes. The difference between hepatic copper and CT attenuation value was not statistically significant (R = 0.056, p = 0.96). CT value had a positive correlation with the grade of orcein-positive granules (Rho = 0.755, p = 0.0001). We concluded that the CT attenuation value of liver can be elevated by rich polymerized methalothionein (copper binding protein) in lysosomes.

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Accession: 008518800

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PMID: 7731777



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