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Effect of fat feeding on human intestinal apolipoprotein B mRNA levels and editing


Effect of fat feeding on human intestinal apolipoprotein B mRNA levels and editing



Biochimica et Biophysica Acta 1214(2): 143-147



ISSN/ISBN: 0006-3002

PMID: 7918594

DOI: 10.1016/0005-2760(94)90038-8

Our purpose was to assess the effect of a fat-rich meal on intestinal apolipoprotein B (apoB) mRNA levels and editing. We obtained jejunal biopsies from eight healthy adults in the fasting state and 3 h after a meal containing 1 g/kg of fat. In the fasting state, 93% of the apoB mRNA contained the editing sequence resulting in apoB-48 production. Feeding induced no significant changes in apoB mRNA levels or editing. Our data are consistent with the concept that the significant increase in apoB-48 within triglyceride-rich lipoproteins in postprandial plasma is not due to alterations in apoB gene expression or editing.

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Accession: 008531491

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