+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of follicular size on oocyte retrieval, fertilization, cleavage, and embryo quality in in vitro fertilization cycles: a 6-year data collection

Effect of follicular size on oocyte retrieval, fertilization, cleavage, and embryo quality in in vitro fertilization cycles: a 6-year data collection

Fertility and Sterility 62(6): 1205-1210

Objective: To determine the effect of follicular size, including the size of the leading follicle, on oocyte retrieval, fertilization, cleavage, and embryo quality in IVF cycles based on a large data collection. Design: Retrospective analysis of 1,109 IVF cycles between 1987 and 1993 at the Hospital of the University of Pennsylvania including 606 patients ranging in age from 23 to 49 years. Results: Follicles with a volume ltoreq 1 mL show a significantly lower oocyte recovery rate than follicles with a volume of gt 1 mL. The highest recovery rate (83.5%) was found in follicles with a volume of 3 to 4 mL. Above a follicular volume of 7 mL, the oocyte recovery drops below that observed for follicles between 1 and 7 mL. Fertilization and cleavage rates were also higher in oocytes obtained from follicles gt 1 mL compared with follicles ltoreq 1 mL. Although fertilization rates were fairly stable above volumes of 1 mL, cleavage rates continued to rise to a peak percentage of 92% with volumes between 6 and 7 mL. Leading follicle size did not have an effect on fertilization and cleavage rates of cohort oocytes. Embryo quality was not influenced significantly by follicular volume. Conclusion: Based on this evaluation of a large number of follicles, follicular size is a useful indicator of oocyte recovery, fertilization and cleavage in IVF cycles. For optimal results, the follicular fluid volume in gonadotropin- and hCG-stimulated cycles should be gt 1 mL, which corresponds to a follicle diameter of gt 12 mm, and not larger than 7 mL (24 mm). For timing of hCG administration, the number of adequate size follicles appears to be more important than the size of the leading follicle(s).

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 008532187

Download citation: RISBibTeXText

PMID: 7957985

DOI: 10.1016/s0015-0282(16)57186-6

Related references

Bromocriptine inhibition of anesthesia-induced hyperprolactinemia: effect on serum and follicular fluid hormones, oocyte fertilization, and embryo cleavage rates during in vitro fertilization. Fertility and Sterility 52(4): 627-632, 1989

Soluble Fas concentrations in the follicular fluid and oocyte-cumulus complex culture medium from women undergoing in vitro fertilization: association with oocyte maturity, fertilization, and embryo quality. Journal of the Society for Gynecologic Investigation 11(8): 566-569, 2004

Follicular maturation parameters associated with the failure of oocyte retrieval, fertilization, and cleavage in vitro. Fertility and Sterility 45(1): 51-57, 1986

Relationship between follicular fluid adipocytokines and the quality of the oocyte and corresponding embryo development from a single dominant follicle in in vitro fertilization/intracytoplasmic sperm injection cycles. Clinical and Experimental Reproductive Medicine 41(1): 21-28, 2014

The correlation of follicular fluid cholesterol levels to oocyte fertilization and cleavage in human menopausal gonadotropin human chorionic gonadotropin in vitro fertilization cycles. Journal of In Vitro Fertilization & Embryo Transfer 3(3): 177, 1986

Effect of electroacupuncture on oocyte quality and pregnancy for patients with PCOS undergoing in vitro fertilization and embryo transfervitro fertilization and embryo transfer. Zhongguo Zhen Jiu 31(8): 687-691, 2011

Gonadotropin stimulation for in vitro fertilization and embryo transfer in insulin-dependent diabetics: follicular response, oocyte quality, embryo development, and follicular environment. Fertility and Sterility 53(4): 741-743, 1990

Fertilization and cleavage of mouse oocytes exposed to the conditions of human oocyte retrieval for in vitro fertilization. Fertility and Sterility 51(4): 675-681, 1989

The effect of pentoxifylline on sperm motility, oocyte fertilization, embryo quality, and pregnancy outcome in an in vitro fertilization program. Fertility and Sterility 63(4): 880-886, 1995

Application of image analysis cytometry in follicular fluid cells obtained from in-vitro fertilization cycles: relationships to patient's age, oocyte maturity, fertilizability and in-vitro fertilization outcome. Human Reproduction 11(10): 2200-2207, 1996

The effectiveness of earlier oocyte retrieval in the case of a premature luteinizing hormone surge on hCG day in in vitro fertilization-embryo transfer cycles. Clinical and Experimental Reproductive Medicine 40(2): 90-94, 2013

Evaluation of ultrasonically guided transvesical follicular aspiration for oocyte collection of in vitro fertilization and embryo transfer. Japanese Journal of Fertility & Sterility 31(3): 117-122, 1986

The effect of varicocele ligation on oocyte fertilization and pregnancy after failure of fertilization in in vitro fertilization-embryo transfer. Hinyokika Kiyo. Acta Urologica Japonica 40(8): 683-687, 1994

Human chorionic gonadotrophin and steroid concentrations in follicular fluid: the relationship to oocyte maturity and fertilization rates in stimulated and natural in-vitro fertilization cycles. Human Reproduction 10(11): 2840-2844, 1995

In vitro fertilization of bovine embryos: research on transvaginal and ultrasound oocyte collection, embryo quality, and virus-embryo interactions. Tierarztliche Umschau 53(8): 504-510, 1998