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Effect of propylthiouracil on hepatic microsomal mixed function oxidase and lipid deposition in broiler chicks fed diets with different fat content



Effect of propylthiouracil on hepatic microsomal mixed function oxidase and lipid deposition in broiler chicks fed diets with different fat content



Japanese Poultry Science 31(1): 20-27



The effect of antithyroid agent (propylthiouracil, PTU) on the growth and a mixed function oxidase system (MFO) in hepatic microsomes and the lipid deposition in the liver and adipose tissue was studied in broiler chicks fed a high carbohydrate (HC) or a high fat (HF) diet. Male broiler chicks at 14 day old were fed on HC or HF diet supplemented with 0, 0.0075 or 0.0150% of PTU for 10 days. Dietary fat content or feeding the diet containing 0.0075% PTU did not affect the feed intake and body weight gain, whereas feeding the diet containing 0.0150% PTU decreased those in chicks fed HC diet. PTU administration significantly increased weight of thyroid grands, liver lipid and abdominal fat contents, but decreased plasma thyroxine concentration regardless of the diet. The liver lipid content in chicks fed the HF diet was lower than those of chicks fed the HC diet at identical PTU levels, but the effect was not significant. The contents of cytochrome P-450 and b5 in the hepatic microsome in chicks fed the HF diet were greater than those fed the HC diet regardless of PTU supplementation. PTU administration increased cytochrome P-450 content in chicks fed the HF diet. The result suggested that the increase in dietary fat content improved growth retardation and excessive lipid deposition in broiler chicks induced by the feeding of PTU, and the effects might be, in part, associated with the activation of hepatic microsomal MFO system.

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