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Effect of sulphated glycosaminoglycans on albuminuria in patients with overt diabetic (type 1) nephropathy



Effect of sulphated glycosaminoglycans on albuminuria in patients with overt diabetic (type 1) nephropathy



Nephrology, Dialysis, Transplantation 11(1): 182-185



Decreased expression of heparan sulphate has been shown in the glomerular basement membrane of patients with overt diabetic nephropathy. Low-molecular-weight heparin (LMWH) is a highly sulphated glycosaminoglycan with strong structural and functional similarities to heparan sulphate. In a first study, we set out to assess if LMWH Could decrease the urinary albumin excretion rate (AER) in diabetic patients with overt nephropathy.

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Accession: 008547811

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PMID: 8649631


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