+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Effect of ursodeoxycholic acid on the inflammatory activity of indomethacin-induced intestinal inflammation in rats

Effect of ursodeoxycholic acid on the inflammatory activity of indomethacin-induced intestinal inflammation in rats

Zeitschrift für Gastroenterologie 35(3): 171-178

The beneficial effects of ursodeoxycholic acid (UDCA) in primary biliary cirrhosis are supposed to be mediated in part by immunological mechanisms. In this study, we have tested whether ursodeoxycholic acid also ameliorates intestinal inflammation induced by indomethacin in rats. Intestinal inflammation was induced in rats by two injections of indomethacin (7.5 mg/kg body weight) 24 h apart. To study its effects on acute inflammation, UDCA (10 mg/kg body weight) was given for three days starting with the first administration of indomethacin; for effects on chronic inflammation, UDCA was given 24 h after the first indomethacin injection for eight days. Rats were sacrificed at days 3 and 9, respectively. In acute inflammation a significant decrease of intestinal injury was observed with UDCA treatment (macroscopic score: 3.00 +/- 0.83 vs. 6.55 +/- 0.53 in controls; p < 0.01; microscopic score: 1.66 +/- 0.28 vs. 2.89 +/- 0.35 in controls; p < 0.05). In chronic inflammation the effects of UDCA treatment were less marked due to a general decline in intestinal injury. Nevertheless a significant decrease in the macroscopic injury score (3.67 +/- 0.62 vs. 1.55 +/- 0.29 in UDCA treated rats; p < 0.01) was observed. Also, there was a significant increase in body weight of UDCA treated rats after nine days compared to controls (28.8% vs. 16% increased body weight in controls; p < 0.01). Thus, ursodeoxycholic acid attenuates the severity of acute damage of small bowel and the development of chronic intestinal inflammation induced by indomethacin in rats.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 008551262

Download citation: RISBibTeXText

PMID: 9106980

Related references

The beneficial effect of ursodeoxycholic acid on indomethacin-induced intestinal inflammation is not due to anti-adhesive properties. Gastroenterology 112(4 SUPPL ): A924, 1997

Ursodeoxycholic acid attenuates leukocyte-endothelial cell adhesion in indomethacin-induced intestinal inflammation in the rat. Gastroenterology 108(4 SUPPL ): A774, 1995

Ursodeoxycholic acid ameliorates, but chenodeoxycholic acid exacerbates indomethacin induced inflammation in rats. Gastroenterology 112(4 SUPPL ): A1021, 1997

Ursodeoxycholic acid abrogates oxidative stress and intestinal barrier dysfunction in indomethacin-induced enteropathy. Gastroenterology 122(4 Suppl 1): A-396, April, 2002

Reduction of prostaglandin-phase in hind-paw inflammation and partial failure of indomethacin to exert anti-inflammatory effect in rats on essential fatty acid deficient diet. Prostaglandins 5(5): 495-503, 1974

Bile secretion in rats with indomethacin-induced intestinal inflammation. American Journal of Physiology 270(5 Pt 1): G804-G812, 1996

Soluble Dietary Fibers Can Protect the Small Intestinal Mucosa Without Affecting the Anti-inflammatory Effect of Indomethacin in Adjuvant-Induced Arthritis Rats. Digestive Diseases and Sciences 61(1): 91-98, 2016

Effect of indomethacin on bile acid-phospholipid interactions: implication for small intestinal injury induced by nonsteroidal anti-inflammatory drugs. American Journal of Physiology. Gastrointestinal and Liver Physiology 298(5): G722-G731, 2010

Effect of 16,16-dimethyl PGE2 and indomethacin on bile acid-induced intestinal injury and restitution in rats. Journal of Laboratory and Clinical Medicine 112(6): 735-744, 1988

Potentiation of indomethacin-induced anti-inflammatory response by montelukast in formalin-induced inflammation in rats. Acta Medica Iranica 51(10): 675-680, 2014

Anti-Inflammatory Effects of an Extract of Polygonum hydropiper Stalks on 2,4,6-Trinitrobenzenesulphonic Acid-Induced Intestinal Inflammation in Rats by Inhibiting the NF-κB Pathway. Mediators of Inflammation 2018: 6029135-6029135, 2018

Specific changes of gut commensal microbiota and TLRs during indomethacin-induced acute intestinal inflammation in rats. Journal of Crohn's & Colitis 8(9): 1043-1054, 2015

NF-kappa-B activation and reduction of bile acid secretion in indomethacin induced intestinal inflammation. Hepatology 26(4 PART 2): 294A, 1997

Influence of indomethacin and other anti-inflammatory drugs on mobilization and production of neutrophils: studies with carrageenan-induced inflammation in rats. Journal of Pharmacology and Experimental Therapeutics 214(1): 74-79, 1980

Influence of 2 4 tetra o methylfurfurylidene sorbitol on carrageenan induced inflammation and anti inflammatory and toxic effects of indomethacin in rats. Agents & Actions 12(4): 521-526, 1982