EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Effectiveness of extreme discordant sib pairs to detect oligogenic disease loci


Effectiveness of extreme discordant sib pairs to detect oligogenic disease loci



Genetic Epidemiology 14(6): 879-884



ISSN/ISBN: 0741-0395

PMID: 9433594

DOI: 10.1002/(sici)1098-2272(1997)14:6<879::aid-gepi53>3.0.co;2-j

A method for the genomic screening of quantitative traits using extreme discordant sib pairs (EDSPs) has recently been described by Risch and Zhang [1995; 1996]. For many models relevant to common, genetically complex diseases, EDSPs are the most powerful siblings for detecting linkage. Thus, if such siblings can be identified and collected, powerful studies with reasonable genotyping budgets can be conducted. Using a subset of the GAW10 data, we have simulated a genomic screen using EDSPs. From the 4,780 total families in the first 20 replicates of 239 families, there were 100, 104, 155, 107, and 180 EDSP families for Q1, Q2, Q3, Q4, and Q5, respectively. EDSP data were analyzed for each trait using a modified version of MAPMAKER/SIBS capable of handling extreme discordant sib pairs. Four regions, one for Q1, one for Q2, and two for Q4, were able to exceed a threshold for linkage corresponding to a 0.001 pointwise significance level. In three cases, maximum lod score (MLS) peaks occurred within 3.8 cM of a major gene. In the fourth case, the MLS peak occurred 28.4 cM from a major gene. Omission of parents and an alternative definition of EDSP were also investigated.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008553267

Download citation: RISBibTeXText

Related references

Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268(5217): 1584-1589, 1995

Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. American Journal of Human Genetics 58(4): 836-843, 1996

Extreme discordant sib pairs The design of choice for mapping quantitative trait loci in humans. American Journal of Human Genetics 57(4 Suppl. ): A201, 1995

Evaluation of a restricted likelihood ratio test for mapping quantitative trait loci with extreme discordant sib pairs. Annals of Human Genetics 62(Pt 1): 75-87, 1998

Power to detect quantitative trait loci and to replicate linkage of oligogenic traits. American Journal of Human Genetics 51(4 Suppl. ): A14, 1992

The "possible triangle" test for extreme discordant sib pairs. Genetic Epidemiology 14(6): 833-838, 1997

Mapping loci for genetically complex diseases using discordant sib-pairs. American Journal of Human Genetics 59(4 Suppl. ): A184, 1996

A weighted test using both extreme discordant and concordant sib pairs for detecting linkage. Genetic Epidemiology 20(1): 34-43, 2001

Discordant twin pairs How do they fare vs non-discordant pairs? Does smaller vs larger matter?. American Journal of Obstetrics and Gynecology 185(6 Suppl.): S119, 2001

Linkage analysis of a common oligogenic disease using selected sib pairs. Genetic Epidemiology 12(6): 741-746, 1995

Using discordant sib pairs to map loci for qualitative traits with high sibling recurrence risk. American Journal of Human Genetics 59(6): 1376-1381, 1996

FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. Bmc Medical Genetics 9: 4, 2008

Efficiency robust tests for mapping quantitative trait loci using extremely discordant sib pairs. Human Heredity 55(2-3): 117-124, 2003

The use of discordant sibling pairs for finding genetic loci linked to obesity: practical considerations. International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity 20(6): 553-560, 1996

Efficiency Robust Tests for Mapping Quantitative Trait Loci Using Extremely Discordant Sib Pairs. Human Heredity 55(2-3): 117-124, 2003