Effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin on cardiohemodynamics in anesthetized dogs

Chang, T.H.; Adachi, H.; Okuyama, T.; Mori, N.; Saito, I.; Zhang, K.Y.; Sun, X.D.; Li, J.M.

Zhongguo Yao Li Xue Bao 15(6): 507-510

1994


ISSN/ISBN: 0253-9756
PMID: 7709748
Accession: 008554077

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Abstract
Cardiohemodynamic effects of 3'-angeloyloxy-4'-acetoxy-3', 4'-dihydroseselin (Pd-Ia) isolated from the Chinese medicinal plant Peucedanum praeruptorum Dunn were compared with those of diltiazem (Dil) in anesthetized open-chest dogs. Pd-Ia 3 mg cntdot kg-1 increased coronary blood flow from 25 +- 11 to 58 +- 16 ml cntdot min-1 (n = 7, P lt 0.01) and decreased mean aortic pressure (MAP) from 13 +- 2 to 8 +- 1 kPa (P lt 0.01), rate pressure product (RPP) from 1.9 +- 0.5 to 1.3 +- 0.3 MPa cntdot bpm (P lt 0.05), +dp/dt-max from 246 +- 56 to 160 +- 36 kPa cntdot s-1 (P lt 0.01) and systemic vascular resistance from 19 +- 4 to 12 +- 7 Pa cntdot ml-1 cntdot min-1 (P lt 0.05), together with an increase in HR. Dil showed effects similar to those of Pd-Ia except for a marked decrease in HR. The effects of Pd-Ia on MAP and RPP were approximately one-tenth as potent as those of Dil. The results demonstrated that Pd-Ia was a Ca-2+ channel blocker.