+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effects of CA antagonists on ethanol-induced excitation in habituated and nonhabituated mice: Interaction with stress factors?

Effects of CA antagonists on ethanol-induced excitation in habituated and nonhabituated mice: Interaction with stress factors?

Pharmacology Biochemistry and Behavior 44(4): 791-796

The effects of Ca antagonists on ethanol induced locomotion in habituated (H) and nonhabituated (NH) mice was examined. H-mice were exposed to the testing apparatus for 4 days before testing. Mice were pretreated with pimozide (D-2 antagonist), Schering 23390 (D-1 antagonist), phenoxybenzamine (alpha-1 antagonist), or yohimbine (alpha-2 antagonist). Mice were then treated with ethanol. H mice had lower activity scores compared to NH mice. Ethanol produced an increase in activity for both groups. In NH animals, pimozide attenuated excitation in inverse relation to the ethanol dosage. In H mice, pimozide attenuated excitation only at doses that in themselves produced a decrease in activity. Schering 23390 reduced excitation only at doses that affected activity per se in both groups. Phenoxybenzamine reduced excitation dose-dependently in both groups. Yohimbine decreased excitation in both groups. Results suggest that stress emanating from a novel environment may affect not only activity per se but also the interaction between CA antagonists and ethanol.

Accession: 008554579

Download citation: RISBibTeXText

PMID: 8385782

DOI: 10.1016/0091-3057(93)90007-g

Download PDF Full Text: Effects of CA antagonists on ethanol-induced excitation in habituated and nonhabituated mice: Interaction with stress factors?

Related references

Interaction between gaba antagonists and ethanol induced locomotor excitation in habituated and non habituated mice. Alcoholism Clinical & Experimental Research 14(2): 304, 1990

Differential effects of catecholamine antagonists on ethanol-induced excitation in mice. Psychopharmacology 102(2): 234-238, 1990

Differential effects of 9 -THC on locomotor behavior in activity-wheel-habituated and nonhabituated rats. Pharmacology 9(1): 41-51, 1973

Differential effects of delta 9 tetra hydro cannabinol on loco motor behavior in activity wheel habituated and nonhabituated rats. Pharmacology (Basel) 9(1): 41-51, 1973

Effects of ethanol on locomotor depression and corticosterone release induced by restraint-stress: support for a stress-ethanol interaction. Pharmacology, Biochemistry, and Behavior 36(2): 273-278, 1990

Potentiation of ethanol-induced loss of the righting reflex by ascorbic acid in mice: Interaction with dopamine antagonists. Pharmacology Biochemistry & Behavior 66(2): 413-418, June, 2000

Effects of 5-HT3 receptor antagonists on ethanol-induced hyperlocomotion in mice. Polish Journal of Pharmacology 47(4): 293-297, 1995

Ethanol-stress interaction: immediate versus delayed effects of ethanol and handling on stress responses of ethanol-consuming rats. Alcohol 4(5): 391-394, 1987

Effects of vasopressin antagonists on ACTH and corticosterone secretion in stress condition induced by ethanol. European Journal of Endocrinology 130(SUPPL 2): 152, 1994

Effects of GABA antagonists and habituation to novelty on ethanol-induced locomotor activity in mice. Alcohol and Alcoholism 26(3): 315-322, 1991

Differential behavioral interactions between the dopamine d 1 antagonist sch 23390 and the dopamine d 2 antagonists metoclopramide and sulpiride in nonhabituated mice. Pharmacology Biochemistry & Behavior 35(2): 285-290, 1990

Stress sensitization of ethanol withdrawal-induced reduction in social interaction: Inhibition by CRF-I and benzodiazepine receptor antagonists and a 5-HT1A-receptor agonist. Neuropsychopharmacology 29(3): 470-482, March, 2004

Effects of dopamine receptor antagonists on the acquisition of ethanol-induced conditioned place preference in mice. Psychopharmacology 231(3): 459-468, 2015

Gastroprotective effects of Kangfuxin-against ethanol-induced gastric ulcer via attenuating oxidative stress and ER stress in mice. Chemico-Biological Interactions, 2016

Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response. Alcohol 51: 89-100, 2016