EurekaMag
+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Effects of galanin on passive avoidance response, elevated plus-maze learning, and spontaneous alternation performance in mice


Effects of galanin on passive avoidance response, elevated plus-maze learning, and spontaneous alternation performance in mice



Peptides 16(7): 1283-1286



ISSN/ISBN: 0196-9781

PMID: 8545252

DOI: 10.1016/0196-9781(95)02009-l

The present study was done to characterize the effects of intracerebroventricular injection of galanin (GAL) on memory processes by observing passive avoidance response, elevated plus-maze learning, and spontaneous alternation performance in mice. An intermediate dose (3 mu-g) of GAL (3 mu-g) significantly decreased step-down latency of passive avoidance response when given 15 min before training, whereas in particular the middle doses (0.3 and 1 mu-g) of GAL significantly decreased it when given 15 min before retention tests. However, GAL (0.3-10 mu-g) was ineffective when given immediately after training. Physostigmine (0.2 mg/kg), a cholinesterase inhibitor, and oxotremorine (0.01 and 0.03 mg/kg), a cholinergic agonist, significantly inhibited the shortening of step-down latency induced by GAL (0.3 mu-g) administered 15 min before retention tests, indicating the involvement of cholinergic dysfunction in the GAL (0.3 mu-g)-induced shortening of step-down latency. In contrast, GAL (0.3-3 mu-g) failed to influence transfer latency in elevated plus-maze learning or percent alternation in spontaneous alternation performance. These results suggest that the activation of cholinergic neurons improves memory dysfunctions induced by GAL, which primarily impairs retrieval processes of memory. The lack of effects of GAL on the elevated plus-maze learning and spontaneous alternation performance may result from the selective effects of GAL in different learning paradigms.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008568173

Download citation: RISBibTeXText

Related references

Effects of Tyr-d-Arg-Phe--Ala-Nh2, a novel dermorphin analog, on elevated plus-maze learning and spontaneous alternation performance in mice. General Pharmacology: The Vascular System 29(3): 453-456, 1997

Effects of Tyr-D-Arg-Phe-beta-Ala-NH2, a novel dermorphin analog, on elevated plus-maze learning and spontaneous alternation performance in mice. General Pharmacology 29(3): 453-456, 1997

Effects of galanin on passive avoidance response in mice. Japanese Journal of Pharmacology 64(Suppl 1): 125P, 1994

Dopaminergic involvement in improving effects of dynorphin A-(1-13) on galanin-induced impairment of passive avoidance learning in mice. Human Psychopharmacology 12(3): 243-248, 1997

Effects of citalopram on cognitive performance in passive avoidance, elevated plus-maze and three-panel runway tasks in naïve rats. Chinese Journal of Physiology 54(1): 36-46, 2011

Limbic networks and associative learning II Entorhinal contributions to spontaneous alternation, passive avoidance, and taste aversion learning. Current Psychology 12(4): 283-295, 1993-, 1994

Limbic networks and associative learning. II: Entorhinal contributions to spontaneous alternation, passive avoidance, and taste aversion learning. Current Psychology (New Brunswick, Nj) 12(4): 283-295, 1993

Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze. Behavioural Brain Research 196(2): 254-260, 2009

Effects of early postnatal AF64A treatment on passive avoidance response and radial maze learning in rats. Nihon Shinkei Seishin Yakurigaku Zasshi 18(2): 39-44, 1998

Intrahippocampal af 64a effects on passive avoidance learning radial arm maze performance open field activity and sensitivity to cholinergic drug challenge. Trends in Pharmacological Sciences (Suppl): 90, 1988

Learning behaviour in chronic vitamin E-deficient and -supplemented rats: radial arm maze learning and passive avoidance response. Behavioural Brain Research 51(2): 157-164, 1992

The effects of an alkylating analog of oxotremorine on passive avoidance memory and spontaneous alternation behavior. Federation Proceedings 44(4): 895, 1985

Calcium channel antagonists enhance retention of passive avoidance and maze learning in mice. Neurobiology of Learning and Memory 75(1): 77-90, 2001

Modulation of spontaneous alternation performance of mice treated with thioperamide and tacrine in a cross maze task. Fundamental and Clinical Pharmacology 19(5): 531-532, 2005

7-Nitroindazole, a neuronal nitric oxide synthase inhibitor, impairs passive-avoidance and elevated plus-maze memory performance in rats. Pharmacology Biochemistry and Behavior 87(4): 434-443, 2007