Effects of insulin and nasal absorption enhancers on ciliary activity
Jian, L.; Po, A.L.W.n
International Journal Of Pharmaceutics (amsterdam). 95(1-3): 101-104
The potential ciliotoxicities of insulin and of the protein absorption enhancers, aprotinin and sodium cholate, were investigated by monitoring the decay in beat frequency of rat cilia exposed to them. Comparison of the area under the ciliary beat frequency decay curves indicates that insulin is relatively non-ciliotoxic over the time exposures studied. Aprotinin, a peptidase inhibitor and sodium cholate, a surface active bile salt, were both highly ciliotoxic. When admixed those two absorption enhancers showed additive rather than synergistic ciliotoxicity. The data suggest that those compounds exerts a direct toxic effect on the cilial membranes. Use of those additives in intranasal formulations is therefore contraindicated.