+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil

, : Effects of sodium diethyldithiocarbamate on ischemia-reperfusion-induced brain injury in Mongolian gerbil. Zhongguo Yao Li Xue Bao 15(5): 469-472

Brain injury in Mongolian gerbil (Merisones unguiculatus) was induced by occluding bilateral common carotid arteries for 60 min followed by reperfusion for 5 or 30 min. Oxygen free radicals in brain tissue were measured by electron spin resonance (ESR) technique malondialdehyde (MDA) was measured by fluorescence spectrometry, and superoxide dismutase (SOD) was measured by nitrite kit. Oxygen free radicals and MDA were not significantly increased, but activities of T-SOD and Mn-SOD were decreased after 60 min of cerebral ischemia. The free radicals were increased at 5-min reperfusion, and then reduced to the level of ischemia group after 30-min reperfusion. MDA was increased remarkably after reperfusion of 30 min, whereas the activity of SOD continued to decrease. Sodium diethyldithiocarbamate (DTC), iv 5-100 mg cntdot kg-1 15 min before occlusion, decreased the production of MDA and increased the activities of T-SOD and MnSOD. The formation of oxygen free radicals was depressed by iv DTC 50 mg cntdot kg-1. The result suggested that the protective effects of DTC on ischemia-reperfusion-induced brain injury might be induced by scavenging the oxygen free radicals, increasing the Mn-SOD activity and decreasing the production of MDA.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 008581279

PMID: 7717079

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

ARDAN, N.I.; JANES, J.M.; HERRICK, J.F., 1957: Ultrasonic energy and surgically produced defects in bone. Defects were made in the midshaft of the femur in 67 dogs. The lateral aspects of the right thigh were exposed to varying amounts of ultrasonic energy with a frequency of 800 kilocycles. Two needle thermocouples were inserted into the bone at each...

McPhail, L.T.; Plunet, W.T.; Das, P.; Ramer, M.S., 2005: The astrocytic barrier to axonal regeneration at the dorsal root entry zone is induced by rhizotomy. After dorsal rhizotomy, sensory axons fail to regenerate beyond the astrocytic glia limitans at the dorsal root entry zone (DREZ) but this inhibition can be overcome with the delivery of exogenous neurotrophin-3. We investigated whether axonal inh...

Spuris, Zandis., 1995: In memoriam Imants Damroze 1938-1993 Entomologa Imanta Damrozes 1938-1993 atcerei. Latvijas Entomologijas Arhivs, 1: 35-37

Goodwin, Anne M.; Gore, Veronica, 2000: Managing the stresses of nursing people with severe and enduring mental illness: A psychodynamic observation study of a long-stay psychiatric ward. The task of nursing people with severe and enduring mental illness can evoke stresses and anxieties for staff which are not consciously known about, but which, nevertheless, impinge upon the quality of care delivered. As a way of exploring this is...

Dagostino M.; Lee C.O., 1982: Neutral carrier sodium selective and calcium selective micro electrodes for intra cellular application. Na+- and Ca2+-selective microelectrodes were made with Simon's neutral carrier ETH 227 and ETH 1001, respectively, and their properties were studied for intracellular application. The kNaK (selectivity coefficient for Na+ with respect to K+)...

Street G. J.; Engel R., 1987: The use of geophysics in defining the causes of dryland salinity in south-western Australia. Exploration Geophysics 18(1-2): 207-210

Smesrud, Jk; Selker, Js, 1999: Postharvest water requirements of peppermint. Peppermint (Mentha piperita var.) is a perennial field crop that is commonly irrigated following harvest to promote fall regrowth. A field study was conducted to measure the consumptive use of peppermint in the postharvest period and to develop cr...

Jacobs, B. L.; Fornal, C. A.; Martin, F. J.; Metzler, C. W., 1996: The ability of WAY-100635 to increase serotonergic neuronal activity after acute fluoxetine treatment is dependent on behavioral arousal. Society for Neuroscience Abstracts 22(1-3): 181

Inoue, Hiroaki; Yajima, Yousuke; Kawano, Genji; Nagasawa, Hiromichi; Sakuda, Shohei, 2004: Isolation of indole-3-aldehyde as a growth inhibitor of Legionella pneumophila from Diaion HP-20 resins used to culture the bacteria. The addition of Diaion HP-20 resin to a medium can enhance the growth of the Legionella species. We recently reported that elemental sulfur was isolated as a growth-inhibiting substance produced endogenously by Legionella pneumophila from the meth...

Merrill, R.M., 2001: Partitioned prostate cancer prevalence estimates: an informative measure of the disease burden. Study objectives: Public health burden of disease is often measured using prevalence statistics. Prevalence of invasive prostate cancer in the United States is presented according to age at diagnosis, time from diagnosis, geographical area, and tw...