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Efficacy and safety of the treatment with magaldrate and dimethicone in acid-peptic disease

Efficacy and safety of the treatment with magaldrate and dimethicone in acid-peptic disease

Investigacion Medica Internacional 21(3): 102-107

The objective was to study the efficacy and tolerance of magaldrate 800 mg and dimeticone 100 mg in a Mexican population with peptic-acid disease. This was a phase IV lt open, multicentric, prospective, longitudinal clinical trail in 691 patients with peptic-acid disease. The score symptoms were: epigastric pain, either diurnal, nocturnal or both; nausea, vomit, retching,pirosis, acid regurgitation, abdominal distention,and delayed gastric emptying. These symptoms were compared after the treatment with magaldrate-dimeticone, four weeks later. We analyzed the tolerance and compliance to the treatment as well as the concomitant medication. All the symptoms had a significant improvement at the end of the trial (p lt 0.001). In 91% of the cases, magaldrate-dimeticone wa., given alone for the treatment of such symptoms and 95% of the patients referred a fast or adequate relief of the symptoms, 97% of the patients stated that they would take again the drug, which was very well tolerated. magaldrate-dimeticone showed to be effective and well tolerated for the relief of symptoms in the peptic-acid disease.

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Accession: 008587384

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