+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Efficacy and safety of the treatment with magaldrate and dimethicone in acid-peptic disease



Efficacy and safety of the treatment with magaldrate and dimethicone in acid-peptic disease



Investigacion Medica Internacional 21(3): 102-107



The objective was to study the efficacy and tolerance of magaldrate 800 mg and dimeticone 100 mg in a Mexican population with peptic-acid disease. This was a phase IV lt open, multicentric, prospective, longitudinal clinical trail in 691 patients with peptic-acid disease. The score symptoms were: epigastric pain, either diurnal, nocturnal or both; nausea, vomit, retching,pirosis, acid regurgitation, abdominal distention,and delayed gastric emptying. These symptoms were compared after the treatment with magaldrate-dimeticone, four weeks later. We analyzed the tolerance and compliance to the treatment as well as the concomitant medication. All the symptoms had a significant improvement at the end of the trial (p lt 0.001). In 91% of the cases, magaldrate-dimeticone wa., given alone for the treatment of such symptoms and 95% of the patients referred a fast or adequate relief of the symptoms, 97% of the patients stated that they would take again the drug, which was very well tolerated. magaldrate-dimeticone showed to be effective and well tolerated for the relief of symptoms in the peptic-acid disease.

(PDF emailed within 1 workday: $29.90)

Accession: 008587384

Download citation: RISBibTeXText


Related references

Long-term, open-label trial: safety and efficacy of continuous maintenance treatment with pantoprazole for up to 15 years in severe acid-peptic disease. Alimentary Pharmacology and Therapeutics 36(1): 37-47, 2012

Evaluation of efficacy, safety and tolerability rabeprazole in treatment of acid-peptic diseases. Arquivos de Gastroenterologia 39(1): 60-65, 2002

Six years of continuous cimetidine treatment in peptic ulcer disease efficacy and safety. Alimentary Pharmacology & Therapeutics 2(5): 395-406, 1988

Efficacy and safety of Syferol-IHP for the treatment of peptic ulcer disease: a pilot, double-blind randomized trial. Clinical and Experimental Gastroenterology 12: 21-30, 2019

Safety and efficacy of a 100% dimethicone pediculocide in school-age children. Bmc Pediatrics 15: 70, 2016

Pantoprazole in severe acid-peptic disease: the effectiveness and safety of 5 years' continuous treatment. Digestive and Liver Disease 37(1): 10-22, 2005

Pantoprazole therapy in the long-term management of severe acid peptic disease: Clinical efficacy, safety, serum gastrin, gastric histology, and endocrine cell studies. American Journal of Gastroenterology 96(6): 1767-1776, 2001

Safety and efficacy of 1-week levofloxacin-based triple therapy in first-line treatment for Helicobacter pylori-related peptic ulcer disease in Kashmir, India. Indian Journal of Gastroenterology 32(1): 32-36, 2013

Comparative study of 3 drugs (aceglutamide aluminum, zinc acexamate, and magaldrate) in the long-term maintenance treatment (1 year) of peptic ulcer. Revista Espanola de Enfermedades Digestivas 80(2): 91-94, 1991

Six years of continuous cimetidine treatment in peptic ulcer disease: efficacy and safety. Anglo-Irish Cimetidine Long-Term Study Group. Alimentary Pharmacology & Therapeutics 2(5): 395-405, 1988

Does dimethicone increase the efficacy of antacids in the treatment of reflux oesophagitis?. Journal of the Royal Society of Medicine 79(10): 584-587, 1986

Efficacy and safety of a 24-week treatment with lansoprazole following healing of peptic lesions resistant to H2 blockers. Gastroenterology 104(4 SUPPL ): A79, 1993

Long-term efficacy and safety of zoledronic acid compared with pamidronate in the treatment of myeloma bone disease. Acta Haematologica Polonica 35(2): 227-241, 2004

Efficacy and safety of omeprazole in the long-term treatment of peptic ulcer and reflux oesophagitis resistant to ranitidine. Digestion 47 Suppl 1: 64-8; Discussion 76, 1990

Assessment of Efficacy and Irritation of Ingenol Mebutate Gel 0.015% Used With or Without Dimethicone Lotion for Treatment of Actinic Keratosis on the Face. Journal of Drugs in Dermatology 16(5): 432-436, 2018