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Enantioselective synthesis of alpha,alpha-disubstituted-alpha-amino acids by a sequential nucleophilic addition to nitriles

Enantioselective synthesis of alpha,alpha-disubstituted-alpha-amino acids by a sequential nucleophilic addition to nitriles

Tetrahedron 54(35): 10525-10535

The sequential addition of two different nucleophiles to a tartaric acid-derived nitrile produced carbinamines. The adducts from chelation-controlled addition which are obtained in high diastereoselectivities and yields, were easily converted to alpha,alpha-disubstituted-alpha-amino acids.

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