Section 9
Chapter 8,605

Endothelin (ET) -3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells

Owada, A.; Tomita, K.; Terada, Y.; Sakamoto, H.; Nonoguchi, H.; Marumo, F.

Journal of Clinical Investigation 93(2): 556-563


ISSN/ISBN: 0021-9738
PMID: 7509343
Accession: 008604625

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We investigated the effects of endothelins on receptor-mediated cyclic nucleotide metabolism in rat glomerulus, inner medullary collecting duct (IMCD), and also in cultured rat glomerular mesangial cells. Endothelin (ET)-3 dose-dependently stimulated cGMP accumulation in glomerulus, which was higher than that of ET-1 or ET-2. ET-B receptor agonist IRL 1620 produced cGMP in a dose-dependent manner, mimicking the effect of ET-3.

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