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Enhanced NMDA conductance can account for epileptiform activity induced by low Mg2+ in the rat hippocampal slice



Enhanced NMDA conductance can account for epileptiform activity induced by low Mg2+ in the rat hippocampal slice



Journal of Physiology 478 Pt 3: 379-393



1. Why does lowering extracellular Mg-2+ cause synchronous neuronal bursts and afterdischarges? To address this question, a computer model of the CA3 region was constructed with 1000 pyramidal neurones and 100 inhibitory neurones. Pyramidal neurones were multicompartmental and contained five ionic conductances, distributed non-uniformly on the membrane. In parallel, experiments were performed on rat hippocampal slices perfused in solutions without added Mg-2+. 2.

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Accession: 008607617

Download citation: RISBibTeXText

PMID: 7965853

DOI: 10.1113/jphysiol.1994.sp020259


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