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Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary restriction in patients with Cushing's syndrome

Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary restriction in patients with Cushing's syndrome

Clinical Endocrinology 48(1): 117-121

OBJECTIVE. In patients with Cushing's syndrome, decreased growth hormone (GH) secretion is observed although the basic mechanism is not yet understood. A short-term hypocaloric diet is known to increase both spontaneous and GHRH-stimulated GH secretion in normal subjects. In order to gain further insight into the altered GH secretion in patients with Cushing's syndrome, we assessed the effect of a short-term hypocaloric diet on GH responses to GHRH in these patients. DESIGN. Two GHRH tests (1 mug/kg i.v.) were performed, the first under basal conditions (normocaloric diet) and the second after a 3-day hypocaloric diet (650 cal/day). PATIENTS. Six female patients with untreated Cushing's disease. MEASUREMENTS. Plasma GH levels were measured by immunoradiometric assay. RESULTS. GHRH-induced GH release was impaired in patients with Cushing's disease on a normal diet (mean peak 12.4 +- 6.4 mU/l, area under the curve (AUC) 744 +- 332 mU/l/120 min). Following a hypocaloric diet, GH responses to GHRH were markedly enhanced in the same group of patients (mean peak 46.2 +- 14.8 mU/l, AUC 3142 +- 1032 mU/l/120 min, P < 0.05). CONCLUSIONS This study demonstrates that In patients with Cushing's disease the somatotroph hyporesponsiveness to growth hormone releasing home is improved after a short-term hypocaloric diet. Therefore, blunted growth-=hormone secretion in chronic hypercortisolism is a potentially reversible state and the secretory capacity of the somatotroph appears not to be severely compromised in patients with Cushing's disease.

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Accession: 008608463

Download citation: RISBibTeXText

PMID: 9509077

DOI: 10.1046/j.1365-2265.1998.00363.x

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