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Estimation of apoptosis in C6 glioma cells treated with antidepressants

Estimation of apoptosis in C6 glioma cells treated with antidepressants

Physiological Research 46(2): 161-164

Gel electrophoresis of DNA was used for estimation of DNA changes caused in C6 glioma cells by treatment with psychotropic drugs (imipramine, amitryptiline and fluoxetine). Some discrete bands containing a population of short DNA fragments appeared after 1 and 5 days of cultivation. Apoptotic DNA breaks were verified at single cell level using the TUNEL test in cells treated with fluoxetine.

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Accession: 008625417

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PMID: 9727508

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