EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Estrogen regulation of dopamine release in the nucleus accumbens: genomic- and nongenomic-mediated effects


Estrogen regulation of dopamine release in the nucleus accumbens: genomic- and nongenomic-mediated effects



Journal of Neurochemistry 62(5): 1750-1756



ISSN/ISBN: 0022-3042

PMID: 8158125

DOI: 10.1046/j.1471-4159.1994.62051750.x

The ability of estrogen to modulate mesolimbic dopamine (DA) was examined using in vivo voltammetry. Estrogen priming (5 micrograms, 48 h) of ovariectomized (ovx) female rats resulted in a slight decrease in K(+)-stimulated DA release measured in the nucleus accumbens: this decrease was accompanied by a significant increase in both DA reuptake and DA clearance times. Following estrogen priming nomifensine, a potent inhibitor of the DA uptake carrier, was still able to potentiate K(+)-stimulated DA release and alter the time course of DA availability, but the response was attenuated compared with ovx controls. Direct infusion of 17 beta-estradiol hemisuccinate (17 beta-E, 20-50 pg) into the nucleus accumbens resulted in a biphasic potentiation of K(+)-stimulated release. An initial increase in release was observed 2 min after 17 beta-E infusion; this increase, although reduced by 15 min, was still significantly higher than control values. A subsequent potentiation was observed 60 min after the initial 17 beta-E infusion; this response remained for at least an additional 60 min. Nomifensine did not significantly alter K(+)-stimulated DA release following 17 beta-E infusion, but was still able to potentiate the total time DA was available extracellularly. These data suggest that the mesolimbic A10 DA neurons that terminate in the nucleus accumbens can be modulated in vivo by estrogen and that this modulation may be mediated by both genomic (long term) and nongenomic (short term) mechanisms.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 008627453

Download citation: RISBibTeXText

Related references

Group II metabotropic glutamate receptor-mediated regulation of dopamine release from slices of rat nucleus accumbens. Neuroscience Letters 404(1-2): 182-186, 2006

Effects of alcohol deprivation on 5-HT3-mediated dopamine release in the nucleus accumbens of P rats. Alcoholism Clinical and Experimental Research 24(5 Suppl): 86A, 2000

Effects of estrogen and progesterone on dopamine release in the nucleus accumbens of the female rat in response to sexually relevant odors and palatable food. Society for Neuroscience Abstracts 22(1-3): 1137, 1996

Differential effects of nicotinic antagonists perfused into the nucleus accumbens or the ventral tegmental area on cocaine-induced dopamine release in the nucleus accumbens of mice. Psychopharmacology 190(2): 189-199, 2007

Effects of amphetamine on carrier-mediated and electrically stimulated dopamine release in slices of rat caudate putamen and nucleus accumbens. Journal of Neurochemistry 64(3): 1161-1168, 1995

Distinctive Modulation of Dopamine Release in the Nucleus Accumbens Shell Mediated by Dopamine and Acetylcholine Receptors. Journal of neuroscience: the official journal of the Society for Neuroscience 37(46): 11166-11180, 2017

Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat. Neurochemical Research 17(5): 401-407, 1992

The effects of acute and chronic haloperidol treatment on dopamine release mediated by the medial forebrain bundle in the striatum and nucleus accumbens. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology 14(3): 211-223, 1996

Evidence for a selective CCK-A and CCK-B receptor mediated regulation of GABA and dopamine release in rat nucleus accumbens A combined receptor binding and microdialysis study. Schizophrenia Research 18(2-3): 147-148, 1996

NMDA receptors in nucleus accumbens modulate stress-induced dopamine release in nucleus accumbens and ventral tegmental area. Synapse 26(3): 225-234, 1997

P2 receptor-evoked glutamate release in the nucleus accumbens is mediated by dopamine. Naunyn-Schmiedeberg's Archives of Pharmacology 365(Suppl 1): R32, 2002

Presynaptic regulation of the release of dopamine and acetyl choline in the nucleus accumbens. Journal of Neurochemistry 41(Suppl): S67, 1983

Local GABA A Receptor-Mediated Suppression of Dopamine Release within the Nucleus Accumbens. Acs Chemical Neuroscience 10(4): 1978-1985, 2019

5-HT3 receptor mediated dopamine release in the nucleus accumbens during withdrawal from continuous cocaine. Psychopharmacology 130(3): 242-248, 1997

Effects of D3/D2 dopamine receptor agonist 7-OH-DPAT on locomotor activity and extracellular dopamine and 5-HT release in the nucleus accumbens. Journal of Neurochemistry 70(Suppl 2): S36, 1998