Ethanol decreases nocturnal plasma levels of atrial natriuretic peptide (ANP 99-126) but not the N-terminal fragment of pro-atrial natriuretic peptide (ANP 1-98) in man
Ekman, A.C.; Vakkuri, O.; Vuolteenaho, O.; Leppäluoto, J.
Clinical Science 86(3): 285-290
ISSN/ISBN: 0143-5221 PMID: 8156739 DOI: 10.1042/cs0860285
1. The aim of this study was to elucidate the role of atrial natriuretic peptides in the regulation of water and electrolyte balance after alcohol intake. To this end we measured the plasma concentrations of ethanol, atrial natriuretic peptide 99-126 and the N-terminal fragment of pro-atrial natriuretic peptide (atrial natriuretic peptide 1-98), serum osmolality and serum sodium concentration, and urine output, urine osmolality and urinary sodium excretion for 12 h after administration of ethanol (0, 0.5 and 1.0 g body weight/kg) and placebo drinks to nine healthy subjects according to a double-blind cross-over design. 2.